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Peptide articles
and guides
Easy-to-read articles on peptide research, dosing, mixing, and the science behind it all.
UV light causes tanning, which is to say and increase of the skin pigment melanin, by stimulating a cellular process mediated by the tumor-suppressor gene _p53_[1]. The whole point of this process is to protect skin cells against UV light, which can damage DNA and lead to problems like cancer, cell death, and the breakdown of extracellular matrix proteins (e.g., collagen) in the skin. This latter effect is what leads to observable skin aging in the form of wrinkles, lines, lost elasticity, and
## Trends in Peptide Research As the ability to synthesize synthetic peptides has grown over the decades since the 1920s, something interesting has happened. Science has slowly but surely moved away from simply trying to mimic the structure of natural peptides, a practice which necessarily limited development to shorter peptides, and has instead focused on developing novel peptides that act on receptors of interest even if they bear no resemblance to native peptides. Trend in peptide len
## Voltage-Gated Sodium Channel NaV1.7 Controls Sensitivity to Pain. NaV1.7 sodium channels are nociceptors controlled by the SCN9A gene. A loss-of-function mutation in gene SCN9A reduces NaV1.7 nociceptor firing, causing CIP (Congenital Insensitivity to Pain) Disease. People born with this mutation are unable to feel most injuries, burns, et al. Conversely, there is a gain-of-function mutation in the SCN9A gene that causes NaV1.7 overactivity. It is associated with heightened pain sens
## CJC 1295 for Weight Loss | What to Know in 2024 CJC 1295 is one of the earliest synthetic derivatives of growth hormone releasing hormone (GHRH). It consists of just the first 29 amino acids of GHRH in combination with a half-life prolonging add-on called DAC. It was created in an effort to produce a more soluble GHRH analogue that was easy to produce in large quantities and which prolonged the effects of GHRH. CJC 1295 is a full agonist of the GHRH receptor. ## CJC 1295 vs CJC 1295 DAC The
## What is B7-33? B7-33 is a novel, synthetic compound that was first discovered and developed by a team of researchers at the Monash University in Australia. The development of B7-33 was based on the discovery of the relaxin receptor 1 (RXFP1) and the recognition of its potential as a therapeutic target for a wide range of diseases and conditions. The research team, led by Professor David Handelsman, first synthesized B7-33 in the early 2010s as part of their efforts to develop a functi
## Cerebrolysin Constituents Nerve Growth Factor: An important protein for development and maintenance of neurons, specifically, neurons involved in pain, temperature, and touch sensation. Nerve growth factor functions by binding to either the NTRK1 receptor or the p75NTR receptor which are both found on the surface of sensory neurons. Brain-Derived Neurotrophic Factor (BDNF): Protein found in the brain and spinal cord that is responsible for growth, maturation, and maintenance of neuron
## SHMOOSE microprotein, a novel mitochondrial DNA variation connected to Alzheimer’s Disease pathology Alzheimer's is a disease that has recently caught the attention of researchers because of the alarming increase in cases through the years. [1,7] This rare but common disorder affects around 6.07 million people in 2020 in the United States. [5] Now, there is no cure for AD. [7] The complexity of AD pathology makes it challenging for investigators to find solutions like treatments for th
## Cerebrolysin and Vascular Dementia ### A Look into the Research: Vascular dementia (VaD) is the second most common form of dementia after Alzheimer's disease (AD). The term 'vascular dementia' refers to a constellation of cognitive and functional impairments all caused by disordered blood flow to the brain. Vascular dementia can be considered a subset of the larger syndrome of vascular cognitive impairment (VCI), that is all cognitive syndromes associated with a cerebrovascular brain injury.
## What is Thymosin Beta-4 (TB4)? Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to produce antibodies. The predominant form of Thymosin, Thymosin Beta 4, is a member of a highly conserved family of actin monomer sequestering proteins. In addition to its role as a major actin-sequestering molecule, Thymosin Bet
## Reestablishing Normal Physiology The answer to combatting adiposity and improving weight loss results is to reestablish normal physiological parameters. Sometimes this is referred to as “hacking your physiology” or “hacking your metabolism,” but it isn’t really hacking. All you are attempting to do is work within the confines of your biochemistry to optimize that very same biochemistry. How you go about doing this, however, depends on your current physiological status and your goals. The fol
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