## Cerebrolysin Constituents Nerve Growth Factor: An important protein for development and maintenance of neurons, specifically, neurons involved in pain, temperature, and touch sensation. Nerve growth factor functions by binding to either the NTRK1 receptor or the p75NTR receptor which are both found on the surface of sensory neurons. Brain-Derived Neurotrophic Factor (BDNF): Protein found in the brain and spinal cord that is responsible for growth, maturation, and maintenance of neuron
Cerebrolysin
Neurogenesis
Parkinson's Research
Parkinson's disease (PD) is a neurodegenerative illness that affects about 1 million people in the United States, and around 90,000 are diagnosed with the disorder every year. [7] The live style of a patient with PD is challenging for the individual and their relatives mainly because of the progression of the disease. PD patients initially presented symptoms associated with the motor system, like postural instability, resting tremor, rigidity, bradykinesia (slowness of movement), or akinesia (
Neurogenesis
Parkinson's Research
Alpha-synuclein (αSyn) is an essential neuronal protein in the nerve terminal that inhibits neurotransmitter release when over-expressed.[8] In general terms, the αSyn preserves the normal function of synapses, which is how information is transmitted between neurons.[8] However, dysfunction of the αSyn protein causes the development of neuropathology. In recent years, the term synucleinopathies has been used to identify progressive neurodegenerative disorders caused by the aggregation of αSy
Neurogenesis
Parkinson's Research
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Alzheimer's Research
Neurogenesis
Parkinson's Research
Programmed cell death, better known as apoptosis, is crucial in eliminating abnormal or unwanted cells in the body.[2] In recent years, the complex pathways regulating apoptosis have been well-studied as potential therapy targets.[2,10] Parkinson's disease (PD) is no exception since the leading cause of this disorder is the death of dopamine-producing neurons in the brain ( **see Fig.1)**.[1-4] PD is a debilitating neurodegenerative disorder that steals a person's ability to control moveme
Neurogenesis
Parkinson's Research
**in Parkinson's disease** The interpretation of the role of oxidative stress in Parkinson's disease (PD) has been vital in the development of experimental therapies.[1,8] Oxidative stress is driven by an inequality of free radicals and antioxidants (defenses).[1] The oxidative stress causes symptoms like muscle pain, memory loss, fatigue, and headache. [1,8] Several articles show that oxidative stress promotes the progression of neuron dysfunction and neuronal mortality. [1,6] Some in
Neurogenesis
Parkinson's Research
Dihexa is a hexapeptide derivative engineered to enhance synaptic connectivity and cognitive processes by activating the HGF/c-Met pathway, showing promise in neuroplasticity research.
Cognition
Neurogenesis
PHDP5 is a synthetic peptide showing promise in reducing beta-amyloid and tau protein accumulation in Alzheimer's disease models.
Alzheimer's Research
Cognition
Neurogenesis