## When Dead Cells Don’t Get Cleaned Up, Diseases Emerge: “This process, termed efferocytosis, is critical for the prevention of autoimmune and inflammatory disorders, and persistence of dead cells in tissue is characteristic of many human autoimmune diseases, notably systemic lupus erythematosus.” (3) “Aberrations in efferocytosis are associated with numerous inflammatory pathologies, including atherosclerosis, cancer and infections. The recent exciting discoveries defining the molecular ma
Cellular Senesence
The aging process is strongly associated with developing diseases, such as cardiovascular conditions, hypertension, cancer, diabetes mellitus, osteoporosis, and neurodegenerative diseases, among others. [10,12] Alzheimer's disease (AD) is no exception since aging is a risk factor for late-onset AD (more than 95% of AD cases). [14,15] Another factor highly associated with aging is the increased cellular senescence population of different cell types as we approach older ages ( **see Fig. 3)**.
Alzheimer's Research
Cellular Senesence