How does PNC-27 selectively target certain types of cancer cells?
“The results strongly suggest, that **PNC-27** (and by inference PNC-28) **is inserted in the plasma membrane of cancer cells upon binding to HDM2**, where, by random movement, the HDM2-PNC-27 complexes assemble into oligomers and eventually into membrane pores. Influx of free PNC-27 molecules through the newly formed membrane pores into the cells... **cytoplasm leads to the assembly of pores in mitochondrial membranes and rapid cell death.**” (5)
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