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The Mitochondrial-Derived Peptide MOTS-c promotes metabolic homeostasis and longevity by improving exercise capacity, reducing obesity and insulin resistance
### MOTS-c treatment enhances physical excercise capacity. "Aging is accompanied by a progressive decline in mitochondrial function and loss of metabolic homeostasis, in which MOTS-c may play a role. Aging is associated with reduced MOTS-c levels in certain tissues, including the skeletal muscle, and in circulation. We previously showed that an acute one-week MOTS-c treatment reversed age-dependent insulin resistance in mouse skeletal muscle. Thus, we investigated if promoting metabolic homeost
MOTS-c treatment enhances physical excercise capacity. "Aging is accompanied by a progressive decline in mitochondrial function and loss of metabolic homeostasis, in which MOTS-c may play a role. Aging is associated with reduced MOTS-c levels in certain tissues, including the skeletal muscle, and in circulation. We previously showed that an acute one-week MOTS-c treatment reversed age-dependent insulin resistance in mouse skeletal muscle. Thus, we investigated if promoting metabolic homeost
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Cellular Energy (Mitochondrial Function)Insulin Sensitization (Blood Sugar Stabilization)MOTS-c
## MOTS-c Doubles Running Capacity of Old Mice. “See how they run: ‘Exercise protein’ doubles running capacity, restores function and extends healthy lifespans in older mice Animal and human data reveal new target for reversing age-related decline, according to USC study.” See how they run: ‘Exercise protein’ doubles running capacity & extends healthy lifespan in old mice - YouTube [Photo image of USC Leonard Davis School of Gerontology](https://www.youtube.com/ch
Bone Density / OsteoporosisCellular Energy (Mitochondrial Function)Insulin Sensitization (Blood Sugar Stabilization)
How Does MOTS-c Affect Performance? It is widely accepted that regular physical activity is beneficial for cardiovascular health. Frequent exercise is robustly associated with a decrease in cardiovascular mortality as well as the risk of developing cardiovascular disease (CVD). Physically active individuals have lower blood pressure, higher insulin sensitivity, and a more favorable plasma lipoprotein profile. Animal models of exercise show that repea
Cardiac FunctionCellular Energy (Mitochondrial Function)Insulin Sensitization (Blood Sugar Stabilization)