Dual mitochondrial support for cellular energy and metabolic health
Quickstart Highlights
- Dosage: 10-15mg combined
- Frequency: Weekly or 2-3x weekly
- Administration: Subcutaneous
- Cycle length: 8-12 weeks
How This Works
Mechanism of Action
How MOTS-c/SS-31 Works in Your Body
Peptide Administered
Enters the bloodstream via injection
Receptor Binding
Finds and activates its target receptor
Signal Cascade
Triggers a chain of cellular responses
Biological Effect
The body produces the desired outcome
Benefits & Side Effects
Potential Benefits
- Mitochondrial optimization
- Energy
- Metabolic health
- Anti-aging
Quick notes
Cutting-edge mitochondrial support. Research is ongoing but promising
Community Insights
Summarised from 1 sourceBased on the Reddit discussion, MOTS-c and SS-31 are peptides that users are exploring for various health benefits. The primary discussion revolves around finding appropriate dosages, particularly for a 41-year-old female, and understanding the potential benefits and interactions with other supplements. Users suggest that MOTS-c may help with metabolic health, energy, and insulin sensitivity, while SS-31 is often mentioned in the context of mitochondrial health and anti-aging. There's a clear emphasis on starting with lower doses and titrating up, and the community shares differing perspectives on combining these peptides with other compounds like metformin or berberine.
Key Benefits
- Improved metabolic health
- Increased energy
- Better insulin sensitivity
- Mitochondrial support
- Anti-aging effects
Common Dosages Reported
- MOTS-c: 5-10mg per week (split into daily or every other day doses)
- SS-31: 1-2mg per day
Stacking Suggestions
- Metformin
- Berberine
- AICAR-C (Alpha-lipoic acid R-isomer, Carnitine)
What people are saying
'I'm trying to figure out which to dose first and then add the other in a week or two... and how to split the dose.'
'I take 10mg of Mots-c every other week, splitting the dose daily... it improved my glucose levels and energy.'
'I would lean towards the Mots-c first and wait a week or two to see how you feel before adding the SS-31.'
Reviews & Discussion
Real experiences shared by the community — not medical advice.
MOTS-c in Cutting Cycle Log
A user documented a cutting cycle utilizing a combination of Testosterone, Retatrutide, and MOTS-c. They noted that the inclusion of MOTS-c was intended to support metabolic health and energy during the fat loss phase.
MOTS-c for Mitochondrial Support in Health Phase
A user reported using MOTS-c as part of a comprehensive 'health phase' cycle that also included Testosterone, Retatrutide, NAD+, and HGH. The focus of the log was on leveraging MOTS-c for mitochondrial support and overall recovery during this protocol.
Injectable Metabolic Modulators for Fatigue Elimination
While initially finding no benefit from an oral version, a user experienced dramatic reductions in training fatigue after switching to an injectable form of a similar compound (SLU-PP-332) at 1-1.5mg daily. They reported feeling capable of training again immediately after a heavy workout, though they did experience a mid-afternoon energy crash that required split dosing to resolve.
Significant Endurance and Work-Capacity Boost from MOTS-c
A user reported that MOTS-c provided a significant and noticeable boost to work capacity and endurance when taken at doses of 2-5mg approximately 30 minutes before a workout. They noted a faster recovery between sets and felt as energized after an hour of high-intensity training as they did upon arrival.
Potential ADHD Stack Mention
A user investigating treatments for ADHD noted that while they have not yet tried the combination, they have heard positive reports regarding the effectiveness of MOTS-C and SS-31 for cognitive enhancement and symptom management.
Stack for Mental Fatigue and PTSD
A user suggested combined use of SS-31 and MOTS-c to treat mental fatigue, burnout, and PTSD. They claimed that SS-31 repairs mitochondria while MOTS-c stimulates the production of healthy new mitochondria, effectively putting them into overdrive.
Brain Recovery Protocol with SS-31 and MOTS-c
A user recommended a specific 16-week protocol involving SS-31, MOTS-c, and NAD+ to address brain recovery after chronic stress or abuse. The regimen involves an initial phase of SS-31 followed by weekly MOTS-c injections to optimize mitochondrial health.
Six-Week MOTS-c Cycle Results
A user reported significant positive effects after completing a six-week cycle of MOTS-c. They experienced a noticeable increase in daily energy levels, improved athletic performance, and faster recovery times.
Starting SS-31 for LC Fatigue
A individual suffering from Long Covid (LC) fatigue sought advice on starting SS-31 for the first time. They expressed interest in proper dosing and supplementary lifestyle adjustments to manage their symptoms.
Microdosing SS-31 and MOTS-c Protocol
A user shared their experience microdosing a blend of these peptides at 500mcg. They reported that the protocol was going well so far during the initial two-week period.
Sequential Use of SS-31 and MOTS-c for Mitochondrial Repair
A longevity reviewer reported positive results when combining the mitochondrial peptides SS-31 and MOTS-c. The user noted that while SS-31 acts to 'clean up' the mitochondria by reducing oxidative stress, following it with MOTS-c helped to 'rebuild' and stimulate mitochondrial biogenesis. This sequential protocol was described as more effective for energy and cellular health than using either peptide in isolation.
Increased Energy and Endurance on MOTS-c Cut
A user began a cutting cycle featuring MOTS-c alongside Testosterone and Retatrutide. They reported significant energy improvements and a noticeable increase in endurance during cardio sessions.
Metabolic and Recovery Support in Health Phase
A user integrated MOTS-c into a professional 'health phase' cycle with NAD and HGH to improve metabolic function. They observed a distinct boost in mitochondrial health and overall recovery speed.
MOTS-c Endurance and Recovery Review
A user reported significant increases in work capacity and endurance when using MOTS-c at 2-5mg pre-workout. They noted a reduction in fatigue between sets and felt as fresh after an hour of training as they did at the start.
Brain recovery protocol after trauma
A user outlined a long-term recovery protocol for brain health involving a multi-week cycle of MOTS-c, SS-31, and NAD+. They suggested specific dosages, such as 5mg of MOTS-c weekly and a total of 112mg of SS-31 over the course of the experiment.
Mitochondrial repair for mental fatigue
A user recommended a combination of SS-31 and MOTS-c to treat mental fatigue, burnout, and PTSD. They claimed that SS-31 works by repairing mitochondria while MOTS-c encourages the replication of these healthy mitochondria.
Increased Energy and Faster Recovery
A user completed a six-week cycle of MOTS-c and experienced a significant increase in daily energy levels. They noted improvements in their ability to train harder and observed faster recovery times between physical activities.
SS-31 for Long Covid Fatigue
A user is beginning a regimen of SS-31 specifically to address chronic fatigue associated with Long Covid. They are seeking guidance on optimal dosing strategies and complementary supplements to support mitochondrial health.
Microdosing Protocol Inquiry
A user reported following a microdosing protocol for a mitochondrial peptide regimen, starting with 500mcg doses over the first two weeks. They are evaluating the effectiveness of this low-dose approach for long-term maintenance.
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