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MOTS-c 1 min read January 28, 2026

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SS-31 and MOTS-c: Peptides Targeting Mitochondrial Function and Aging

Related Peptides

MOTS-c

Mitochondrial peptide for metabolic regulation, exercise capacity, and insulin sensitivity. MOTS-c is a mitochondrial-derived peptide (MDP) that acts as an exercise mimetic, improving glucose metabolism and insulin sensitivity. It's particularly promising for metabolic syndrome and age-related metabolic decline.

Metabolic regulation Exercise mimetic

MOTS-c/SS-31 Blend

Dual mitochondrial support for cellular energy and metabolic health

Mitochondrial optimization Energy

SS-31 (Elamipretide)

SS-31 (Elamipretide/Bendavia) is a mitochondria-targeted tetrapeptide that binds to cardiolipin in the inner mitochondrial membrane. It optimizes mitochondrial function, reduces oxidative stress, and has potential applications in aging, heart failure, and mitochondrial diseases.

Mitochondrial optimization Cardiolipin binding

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MOTS-c

The Mitochondrial-Derived Peptide MOTS-c promotes metabolic homeostasis and longevity by improving exercise capacity, reducing obesity and insulin resistance

### MOTS-c treatment enhances physical excercise capacity. "Aging is accompanied by a progressive decline in mitochondrial function and loss of metabolic homeostasis, in which MOTS-c may play a role. Aging is associated with reduced MOTS-c levels in certain tissues, including the skeletal muscle, and in circulation. We previously showed that an acute one-week MOTS-c treatment reversed age-dependent insulin resistance in mouse skeletal muscle. Thus, we investigated if promoting metabolic homeost

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How Does MOTS-c Improve Metabolism, Endurance, and Bone Strength?

## MOTS-c Doubles Running Capacity of Old Mice. “See how they run: ‘Exercise protein’ doubles running capacity, restores function and extends healthy lifespans in older mice Animal and human data reveal new target for reversing age-related decline, according to USC study.” See how they run: ‘Exercise protein’ doubles running capacity & extends healthy lifespan in old mice - YouTube [Photo image of USC Leonard Davis School of Gerontology](https://www.youtube.com/ch

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MOTS-c

MOTS-c Enhances Heart and Exercise Capacity

How Does MOTS-c Affect Performance? It is widely accepted that regular physical activity is beneficial for cardiovascular health. Frequent exercise is robustly associated with a decrease in cardiovascular mortality as well as the risk of developing cardiovascular disease (CVD). Physically active individuals have lower blood pressure, higher insulin sensitivity, and a more favorable plasma lipoprotein profile. Animal models of exercise show that repea

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