How Does MOTS-c Improve Metabolism, Endurance, and Bone Strength?

The Mitochondrial-Derived Peptide MOTS-c promotes metabolic homeostasis and longevity by improving exercise capacity, reducing obesity and insulin resistance

### MOTS-c treatment enhances physical excercise capacity. "Aging is accompanied by a progressive decline in mitochondrial function and loss of metabolic homeostasis, in which MOTS-c may play a role. Aging is associated with reduced MOTS-c levels in certain tissues, including the skeletal muscle, and in circulation. We previously showed that an acute one-week MOTS-c treatment reversed age-dependent insulin resistance in mouse skeletal muscle. Thus, we investigated if promoting metabolic homeost

MOTS-c Enhances Heart and Exercise Capacity

How Does MOTS-c Affect Performance? It is widely accepted that regular physical activity is beneficial for cardiovascular health. Frequent exercise is robustly associated with a decrease in cardiovascular mortality as well as the risk of developing cardiovascular disease (CVD). Physically active individuals have lower blood pressure, higher insulin sensitivity, and a more favorable plasma lipoprotein profile. Animal models of exercise show that repea

SS-31 and MOTS-c: Peptides Targeting Mitochondrial Function and Aging