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PE-22-28 1 min read January 28, 2026

Can Peptides PE-22-28 and SS-31 work together to improve mood, memory, and the heart?

## TREK1 Inhibition Reduces Heart Fibrosis but Worsens Heart Enlargement (Hypertrophy) by Increasing Calcineurin/NFAT. In response to pathological pressure overload stress, TREK-1–KO mice develop increased concentric hypertrophy and changes in fetal gene expression, but show preserved systolic and diastolic cardiac function.

TREK1 Inhibition Reduces Heart Fibrosis but Worsens Heart Enlargement (Hypertrophy) by Increasing Calcineurin/NFAT. In response to pathological pressure overload stress, TREK-1–KO mice develop increased concentric hypertrophy and changes in fetal gene expression, but show preserved systolic and diastolic cardiac function.

Tags
Cardiac Function Cellular Energy (Mitochondrial Function) Cognition Neurogenesis PE-22-28 SS-31

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PE-22-28 (Spadin)

Spadin analog that blocks TREK-1 potassium channels for rapid antidepressant effects. PE-22-28 works through a novel mechanism distinct from traditional antidepressants, showing rapid onset of action in research studies.

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