SLU-PP-332 is a small molecule ERRα (estrogen-related receptor alpha) agonist that enhances mitochondrial function and endurance without exercise. It activates the same pathways as endurance training, increasing oxidative muscle fibers and exercise capacity.
Endurance & Output
Performance peptides raise cellular energy output and oxygen efficiency.
Quickstart Highlights
- Dosage: Research dosing
- Frequency: Research plans
- Administration: Research - oral or injection
- Cycle length: Research plans
How This Works
SLU-PP-332 is an agonist of ERRα, a nuclear receptor that controls mitochondrial biogenesis, oxidative metabolism, and the slow-twitch muscle fiber program. Activation of ERRα mimics the transcriptional effects of endurance training, increasing mitochondrial content, oxidative enzyme expression, and converting fast-twitch to slow-twitch muscle fibers, improving endurance capacity.
Mechanism of Action
How SLU-PP-332 Works in Your Body
Peptide Administered
Enters bloodstream pre-activity
Mitochondrial Boost
Enhances cellular energy production
Oxygen Efficiency
Improves VO2 max and endurance capacity
Peak Performance
Greater stamina, power, and recovery speed
Benefits & Side Effects
Potential Benefits
- Increased endurance capacity
- Mitochondrial biogenesis
- Muscle fiber type conversion
- Improved oxidative metabolism
- Exercise-like adaptations
- Potential therapeutic for muscle wasting
Potential Side Effects
- Unknown - no human studies
- Potential hormonal effects (ERR pathway)
- May be banned in competitive sports
- Research compound only
Good to know
- NOT a peptide - small molecule ERRα agonist.
- Activates same pathways as endurance exercise.
- Increases type I (oxidative) muscle fibers.
- Research compound - no human clinical trials yet.
- May be considered doping if used in sports.
- Works differently than AICAR (AMPK vs ERRα).
- Preclinical research only.
Community Insights
Summarised from 2 sourcesSLU-PP-332 is a small molecule ERRα (estrogen-related receptor alpha) agonist that enhances mitochondrial function and endurance without exercise. It activates the same pathways as endurance training, increasing oxidative muscle fibers and exercise capacity. ERRα agonist. Exercise mimetic. Researc
Common Dosages Reported
- Research dosing Research plans
- Standard protocol dosing
Side Effects Mentioned
- Generally mild, individual variation expected
- See full guide for detailed safety info
Stacking Suggestions
- Consult research and healthcare provider before stacking
What people are saying
Results vary based on individual response
Consistent dosing and timing important
Reviews & Discussion
Real experiences shared by the community — not medical advice.
Cycle Log: SLU-PP-332 with Retatrutide and HGH
A user initiated a cycle log featuring SLU-PP-332 alongside Retatrutide, HGH, and other compounds for performance and weight management. They expressed optimism about the stack's potential for metabolic enhancement and body recomposition.
Preparation and Administration Guide for SLU-PP-332
A community member provided a guide on the proper preparation and administration of SLU-PP-332. The discussion focused on reconstitution methods and injection protocols to ensure compound stability and efficacy.
Liquid SLU-PP-332 Dosing and Administration
A user inquired about the efficacy of a liquid SLU-PP-332 formulation at a concentration of 1000 mcg/ml. While they were unsure about sublingual absorption, another member suggested that a dosage of 500 mcg twice daily should be sufficient based on current research standards.
Dosage Discrepancies and Metabolic Potential
A member discussed the potential of SLU-PP-332 as an 'exercise mimetic' for fat loss and metabolic health but expressed concerns regarding the correct human equivalent dosage. They noted a significant discrepancy between common user dosages (500 mcg twice daily) and the mathematical conversions from mouse studies, which might suggest a much higher required dose.
Skepticism Toward Oral Bioavailability and Micro-dosing
A user reported using 750 mcg of oral SLU-PP-332 daily and questioned if the perceived endurance benefits and slightly drier physique were merely a placebo effect. They expressed skepticism regarding oral bioavailability, citing that current human doses appear to be micro-doses compared to those used in successful animal studies.
Oral SLU-PP-332 Ineffective at Low Doses
A user reported that an oral version of SLU-PP-332 was a complete failure, providing no changes in body fat, training performance, cardio, or energy levels at doses ranging from 500 mcg to 2 mg per day. The user noted no effects even after 37 days of use.
Injectable SLU-PP-332 Enhances Recovery and Eliminates Fatigue
A user experienced significant improvements in recovery and a total lack of training-induced fatigue when switching to an injectable version of SLU-PP-332 at 1 mg to 1.5 mg per day. While the user initially experienced a severe afternoon energy crash, they successfully mitigated this by splitting the dose into 1 mg in the morning and 500 mcg at noon.
Dosing Skepticism
A user expressed skepticism regarding the common dosing recommendation of 250mcg twice daily for SLU-PP-332. They suggested that these dosages originate from influencer marketing rather than proven efficacy, implying the peptide may be less effective at those levels than claimed.
Inquiry regarding metabolic vs. cognitive effects of SLU-PP-332
A user questioned whether SLU-PP-332 should be categorized as a nootropic, noting that it primarily targets metabolic functions in the body rather than direct cognitive enhancement. They characterized it as an exercise mimetic rather than a traditional mind-focused substance.
No results at low dosage
A user reported seeing and feeling zero effect after taking 1mg of the peptide several times per day. They expressed skepticism regarding the low dosage and mentioned plans to increase the dose significantly to see if it yields results.
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