AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) is a research compound that activates AMP-activated protein kinase (AMPK), earning the nickname 'exercise pill' after studies showed sedentary animals given AICAR experienced dramatic endurance improvements.
Endurance & Output
Performance peptides raise cellular energy output and oxygen efficiency.
Quickstart Highlights
- Dosage: 1-3mg
- Frequency: Daily
- Administration: Subcutaneous
- Cycle length: 2-4 weeks
Dosing Plan
| Weeks | Dose | Units |
|---|---|---|
| Weeks 1–2 | 1000mcg (1mg) | 6 units (0.06mL) |
| Weeks 3–4 | 2000mcg (2mg) | 12 units (0.12mL) |
| Advanced | 3000mcg (3mg) | 18 units (0.18mL) |
How to mix
Add 3.0mL bacteriostatic water per 50mg vial → ~16.7mg/mL concentration
- Draw 3.0mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall.
- Gently swirl until dissolved.
- Label with date and refrigerate at 2–8°C; use within 4 weeks.
Syringe Math Reference
- 50mg vial with 3mL BAC water = 16.7 mg/mL
- 1 unit = 0.01mL ≈ 167mcg
- 1mg dose = 6 units (0.06mL)
- 2mg dose = 12 units (0.12mL)
- 3mg dose = 18 units (0.18mL)
What you'll need
AICAR Vials (50mg)
- 2 weeks 1 vial
- 4 weeks 1-2 vials
Insulin Syringes (U-100)
- 4 weeks 30 syringes
Bacteriostatic Water (10mL)
- 4 weeks 1 bottle
Alcohol Swabs
- 4 weeks 1 × 100-count box
How This Works
AICAR is phosphorylated intracellularly to ZMP, an AMP analog that activates AMP-activated protein kinase (AMPK). AMPK is the master metabolic regulator that is normally activated by exercise. By directly activating AMPK, AICAR mimics some of the metabolic adaptations that occur with endurance exercise, including enhanced fatty acid oxidation, glucose uptake, and mitochondrial biogenesis.
Mechanism of Action
How AICAR Works in Your Body
Peptide Administered
Enters bloodstream pre-activity
Mitochondrial Boost
Enhances cellular energy production
Oxygen Efficiency
Improves VO2 max and endurance capacity
Peak Performance
Greater stamina, power, and recovery speed
Benefits & Side Effects
Potential Benefits
- Improved endurance without exercise
- Enhanced fatty acid oxidation
- Increased mitochondrial biogenesis
- Improved glucose uptake
- Metabolic conditioning
Potential Side Effects
- Hypoglycemia risk
- GI discomfort
- Fatigue
- Limited human safety data
How to store it
- Lyophilized: Freeze at −20°C (−4°F).
- Reconstituted: Refrigerate at 2–8°C; use within 4 weeks.
- Avoid freeze–thaw cycles.
Good to know
- WADA classifies AICAR as a metabolic modulator - prohibited in sports.
- Not approved for therapeutic use in humans.
- Research compound only - use with appropriate caution.
- May cause hypoglycemia - monitor blood sugar.
- Studies showed dramatic endurance improvements in sedentary animals.
Community Insights
Summarised from 2 sourcesAICAR (5-aminoimidazole-4-carboxamide ribonucleoside) is a research compound that activates AMP-activated protein kinase (AMPK), earning the nickname 'exercise pill' after studies showed sedentary animals given AICAR experienced dramatic endurance improvements. WADA prohibited compound. Not approved
Common Dosages Reported
- 1-3mg Daily
- Standard protocol dosing
Side Effects Mentioned
- Generally mild, individual variation expected
- See full guide for detailed safety info
Stacking Suggestions
- Consult research and healthcare provider before stacking
What people are saying
Results vary based on individual response
Consistent dosing and timing important
Reviews & Discussion
Real experiences shared by the community — not medical advice.
Practicality and Bioavailability Concerns
A user expressed skepticism regarding the practical use of AICAR due to its extremely low oral bioavailability. They pointed out that to achieve the results seen in studies, an individual would need very high, potentially cost-prohibitive doses or frequent injections.
AICAR for Endurance and Fat Oxidation
A user explored the application of AICAR alongside resveratrol and PPAR agonists for metabolic health. They noted that while AICAR is effective at activating AMPK to enhance endurance and fat oxidation, the high cost and requirement for large dosages make it difficult to sustain for long-term use.
Cognitive and Metabolic Benefits of AICAR
A user discussed the potential cognitive benefits of AICAR, noting its role as an exercise mimetic that may transiently improve brain function and support neurogenesis. They highlighted its ability to activate AMPK, which could mimic some of the metabolic and neurological advantages of physical exercise.
Improved Cardio Capacity and Energy
A user shared their experience using AICAR for fat loss and endurance, describing it as an incredible compound that allowed them to perform cardio sessions without feeling tired. They reported that the peptide significantly boosted their energy levels and physical output.
Endurance Support for Ironman Training
In a discussion regarding Ironman training, a user recommended AICAR for its ability to enhance endurance and aid in fat loss. They characterized it as a highly effective cardiovascular performance enhancer for long-distance athletes.
Exceptional Endurance Gains for Running
An endurance runner reported significant performance improvements while using AICAR, noting that their cardio felt "limitless" and they could run for miles without becoming winded. They observed a noticeable increase in endurance and a decrease in recovery time during their training log.
AICAR Preparation and Cost Concerns
A user noted that AICAR is typically provided in powder form and requires reconstitution with bacteriostatic water. They expressed significant concern over the cost-to-benefit ratio, suggesting that effective dosages might reach $4,500 per month and carry potential cardiovascular risks.
Endurance and Weight Loss Goals with AICAR
A 250lb user sought advice on using AICAR to improve endurance and assist in fat loss for Brazilian Jiu Jitsu. They expressed confusion over dosing and mentioned the high expense of the compound, hoping a low-dose protocol might still be effective for a naturally large individual.
Low-Dose Injectable AICAR Protocol
A user started a regimen of 25 mg of injectable AICAR per day to evaluate its effectiveness for endurance performance. They intended to report back on results after continuing the protocol beyond the first week.
Equivocal Results and High Costs of AICAR
A general overview of the compound highlights that while it is used by elite cyclists for endurance and fat loss, bodybuilders often find the results equivocal. The report notes that effective doses used in scientific literature are extremely high and potentially cost-prohibitive for humans.
AICAR versus Fragment pros/cons/value/effectiveness
A user expressed interest in using AICAR for fat loss and performance but noted a significant lack of available information regarding effective dosing protocols. They compared it to HGH Fragment 176-191, questioning whether AICAR provides better value given the high costs associated with effective fragment dosing.
A List of Peptides and Their Corresponding Effects
A discussion regarding the safety profile of AICAR highlighted potential risks concerning oncology. Specifically, concerns were raised that the peptide may accelerate the growth of existing tumors under certain circumstances, suggesting a need for caution for those with a history of malignancy.
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