Anti-inflammatory tripeptide derived from alpha-MSH for gut healing and inflammation control. KPV is the C-terminal fragment of alpha-melanocyte stimulating hormone (α-MSH) with potent anti-inflammatory properties. It inhibits NF-κB, reducing inflammation without immunosuppression.
Immune Defense
Immunomodulatory peptides train and strengthen your immune response.
Quickstart Highlights
- Dosage: 200-500mcg
- Frequency: 1-2x daily
- Administration: Subcutaneous or oral
- Cycle length: 4-12 weeks
Dosing Plan
| Weeks | Dose | Units |
|---|---|---|
| Weeks 1–2 (Starting) | 200mcg once daily | 8 units (0.08mL) from 2.5mg/mL |
| Weeks 3–4 (Standard) | 300-500mcg once daily | 12-20 units (0.12-0.2mL) |
| Gut plan | 500mcg 1-2x daily | For IBD, IBS, or leaky gut |
| Oral Capsules | 500mcg-1mg daily | Oral bioavailability for gut-specific effects |
How to mix
2ml BAC water per 5mg vial
- Draw 2.0mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall.
- Gently swirl until completely dissolved.
- Label with date. Concentration = 2.5mg/mL (2,500mcg/mL).
- Refrigerate at 2–8°C. Use within 4 weeks.
Syringe Math Reference
- 5mg vial with 2mL BAC water = 2.5 mg/mL = 2,500 mcg/mL
- 200mcg dose = 8 units (0.08mL)
- 300mcg dose = 12 units (0.12mL)
- 500mcg dose = 20 units (0.2mL)
What you'll need
KPV Vials (5mg)
- 4 weeks (500mcg/day) 2-3 vials
- 8 weeks 4-5 vials
- 12 weeks 6-8 vials
Insulin Syringes (U-100)
- 4 weeks 30 syringes
- 8 weeks 60 syringes
- 12 weeks 90 syringes
Bacteriostatic Water (10mL)
- 4 weeks 1 bottle
- 8 weeks 1-2 bottles
- 12 weeks 2 bottles
Alcohol Swabs
- 4 weeks 1 × 100-count box
- 8 weeks 1 × 100-count box
- 12 weeks 2 × 100-count boxes
How This Works
KPV is a tripeptide (Lysine-Proline-Valine) derived from the C-terminal of alpha-melanocyte stimulating hormone (α-MSH). It exerts potent anti-inflammatory effects primarily through inhibition of NF-κB, the master transcription factor that drives inflammatory gene expression. KPV can enter cells and directly interact with the NF-κB signaling pathway. Unlike steroids, it reduces inflammation without causing immunosuppression, making it ideal for chronic inflammatory conditions.
Mechanism of Action
How KPV Works in Your Body
Peptide Administered
Enters the immune system network
Thymic Activation
Stimulates T-cell maturation in the thymus
Immune Training
Immune cells become more targeted and effective
Defense Strengthened
Better pathogen recognition and response
Benefits & Side Effects
Potential Benefits
- Potent anti-inflammatory without immunosuppression
- Effective for IBD, Crohn's, and ulcerative colitis
- Gut healing and intestinal barrier repair
- Skin inflammation and wound healing
- Can be taken orally for gut-specific effects
- Synergistic with BPC-157 for healing
- No significant side effects reported
Potential Side Effects
- Generally very well-tolerated
- Minimal side effects reported in research
- Injection site irritation (minor, rare)
- One of the safest anti-inflammatory peptides
How to store it
- Lyophilized: Store refrigerated or frozen for long-term stability.
- Reconstituted: Refrigerate at 2–8°C; use within 4 weeks.
- KPV is a stable tripeptide.
- Protect from excessive heat.
Good to know
- Derived from the C-terminal of alpha-MSH (anti-inflammatory hormone).
- Primarily works by inhibiting NF-κB, a master regulator of inflammation.
- Excellent for gut inflammation - IBD, Crohn's, ulcerative colitis, IBS.
- Oral administration specifically targets the GI tract.
- Does not cause immunosuppression - modulates inflammation without blocking immune function.
- Often combined with BPC-157 for comprehensive gut healing.
- Also beneficial for skin conditions like psoriasis and eczema.
- Part of the KLOW blend with TB-500, BPC-157, and GHK-Cu.
Community Insights
Summarised from 3 sourcesAnti-inflammatory tripeptide derived from alpha-MSH for gut healing and inflammation control. KPV is the C-terminal fragment of alpha-melanocyte stimulating hormone (α-MSH) with potent anti-inflammatory properties. It inhibits NF-κB, reducing inflammation without immunosuppression. Derived from α
Common Dosages Reported
- 200-500mcg 1-2x daily
- Standard protocol dosing
Side Effects Mentioned
- Generally mild, individual variation expected
- See full guide for detailed safety info
Stacking Suggestions
- Consult research and healthcare provider before stacking
What people are saying
Results vary based on individual response
Consistent dosing and timing important
Reviews & Discussion
Real experiences shared by the community — not medical advice.
KPV for Anti-Inflammatory Conditions
A user described KPV as being highly effective when used as a topical cream for inflammatory skin conditions like acne, eczema, and psoriasis. They also noted its potential for treating gastrointestinal issues like ulcerative colitis and irritable bowel syndrome when taken orally.
KPV for Skin and Digestive Inflammation
A user reported that KPV is highly effective when used as a topical cream for inflammatory skin conditions such as acne, eczema, and psoriasis. They also noted that the oral form of the peptide is beneficial for managing digestive issues like ulcerative colitis and irritable bowel syndrome.
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