VIP (Vasoactive Intestinal Peptide) dosing guide
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide with potent anti-inflammatory and immunomodulatory properties. It's used in CIRS (Chronic Inflammatory Response Syndrome) plans for mold illness and is known for regulating cytokines, supporting pulmonary function, and modulating the immune response.
Immune Defense
Immunomodulatory peptides train and strengthen your immune response.
Quickstart Highlights
- Dosage: 50-200mcg
- Frequency: 1-4x daily (intranasal)
- Administration: Intranasal spray
- Cycle length: 4-12 weeks or longer for CIRS
Dosing Plan
| Weeks | Dose | Units |
|---|---|---|
| Starting (CIRS plan) | 50mcg 4x daily intranasal | 1-2 sprays per dose |
| Standard plan | 50mcg 4x daily | 200mcg total daily |
| Maintenance | 50mcg 2-4x daily | Titrate based on response |
What you'll need
VIP Nasal Spray (500mcg/mL)
- 4 weeks 1-2 bottles
- 8 weeks 2-3 bottles
- 12 weeks 3-4 bottles
How This Works
VIP is an endogenous neuropeptide that acts on VPAC1 and VPAC2 receptors throughout the body. It has potent anti-inflammatory effects by suppressing pro-inflammatory cytokines (TNF-α, IL-6, IL-12) and shifting immune responses toward Th2/regulatory profiles. VIP also protects epithelial barriers, supports pulmonary function, regulates circadian rhythms, and has neuroprotective properties. In CIRS, it helps normalize dysregulated inflammatory cascades.
Mechanism of Action
How VIP Works in Your Body
Peptide Administered
Enters the immune system network
Thymic Activation
Stimulates T-cell maturation in the thymus
Immune Training
Immune cells become more targeted and effective
Defense Strengthened
Better pathogen recognition and response
Benefits & Side Effects
Potential Benefits
- Reduction in inflammatory markers (C4a, TGF-β1, MMP-9)
- Improved energy and cognitive function in CIRS
- Pulmonary function improvement
- Normalized regulatory T-cell function
- Reduced cytokine storm responses
- Neuroprotective effects
Potential Side Effects
- Generally well-tolerated
- Nasal irritation or congestion
- Possible initial symptom flare in CIRS
- Hypotension (rare, at high doses)
- Diarrhea (rare)
How to store it
- Nasal spray: Refrigerate at 2–8°C.
- Use within 90 days of compounding.
- Protect from heat and light.
Good to know
- Central component of Shoemaker CIRS (mold illness) plan.
- MUST remove from mold exposure before starting VIP.
- Intranasal administration reaches CNS effectively.
- Lab markers should normalize before starting (MARCoNS negative, etc.).
- Regulates multiple inflammatory pathways.
- May improve pulmonary arterial hypertension symptoms.
- Used for its immunomodulatory rather than vasodilatory effects.
- Typically compounded by specialty pharmacies.
Community Insights
Summarised from 3 sourcesVasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide with potent anti-inflammatory and immunomodulatory properties. It's used in CIRS (Chronic Inflammatory Response Syndrome) plans for mold illness and is known for regulating cytokines, supporting pulmonary function, and modulating th
Common Dosages Reported
- 50-200mcg 1-4x daily (intranasal)
- Standard protocol dosing
Side Effects Mentioned
- Generally mild, individual variation expected
- See full guide for detailed safety info
Stacking Suggestions
- Consult research and healthcare provider before stacking
What people are saying
Results vary based on individual response
Consistent dosing and timing important
Reviews & Discussion
Real experiences shared by the community — not medical advice.
VIP Nasal Spray for CIRS and Mold Illness Recovery
A user reported that VIP (Vasoactive Intestinal Peptide) nasal spray was highly effective for managing symptoms of Chronic Inflammatory Response Syndrome (CIRS) and mold illness. They noted that it significantly helped with cognitive function and physical recovery after being cleared of mold exposure.
VIP for Erectile Dysfunction and Smooth Muscle Relaxation
A user discussed the therapeutic potential of vasoactive drugs, noting that VIP (Vasoactive Intestinal Peptide) can be used to treat erectile dysfunction by influencing the function of vascular and non-vascular smooth muscle in penile tissue. In clinical settings, it is often combined with other substances like phentolamine (comprising the drug Bimix) to induce smooth muscle relaxation and facilitate erections.
VIP Stimulates Prolactin Release
A user discussed the hormonal mechanisms of Prolactin, noting that Vasoactive Intestinal Peptide (VIP) is one of the many hormones and neurotransmitters that can stimulate its release. They highlighted that while VIP is a factor, Prolactin regulation is complex and primarily controlled by dopamine inhibition.
Severe Side Effects from VIP Overdose
A user reported experiencing a severe adverse reaction after accidentally overdosing on VIP. They described symptoms including a dramatic drop in blood pressure, intense flushing, and significant cardiovascular distress.
Long-term Side Effects from VIP Nasal Spray
Following five months of low-dose VIP nasal spray use, a user reported developing persistent negative symptoms. They experienced chronic fatigue, heart palpitations, and neurological issues that did not immediately resolve upon discontinuing the peptide.
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