CJC-1295 + Ipamorelin Blend (5mg/5mg) dosing guide
The most popular growth hormone secretagogue blend combining CJC-1295 (GHRH analog) and Ipamorelin (GHRP). This combination maximizes GH release by stimulating both the GHRH and ghrelin pathways while maintaining a favorable safety profile with minimal hunger or cortisol increase.
GH Release Cycle
Secretagogues trigger pulsatile growth hormone release from the pituitary.
Quickstart Highlights
- Dosage: 100-300mcg each
- Frequency: 1-2x daily
- Administration: Subcutaneous injection
- Cycle length: 8-12 weeks, cycle off 4-8 weeks
Dosing Plan
| Weeks | Dose | Units |
|---|---|---|
| Anti-Aging/General | 100mcg each 2x daily | Before bed, optional morning |
| Performance | 200-300mcg each 2x daily | Morning fasted + bedtime |
| Fat Loss Focus | 200mcg each 2-3x daily | Fasted doses throughout day |
How to mix
2ml BAC water for 10mg total
- Add 2mL bacteriostatic water to the 10mg vial.
- Swirl gently until dissolved.
- Concentration: 5mg/mL total (2.5mg/mL each).
- Refrigerate and use within 4-6 weeks.
Syringe Math Reference
- With 2mL reconstitution: 5mg/mL total (2.5mg/mL each)
- 100mcg each (200mcg total) = 4 units (0.04mL)
- 200mcg each (400mcg total) = 8 units (0.08mL)
- 300mcg each (600mcg total) = 12 units (0.12mL)
How This Works
CJC-1295 is a GHRH (growth hormone releasing hormone) analog that amplifies the natural GH pulse. Ipamorelin is a growth hormone releasing peptide (GHRP) that stimulates ghrelin receptors to initiate GH release. Together, they work synergistically: Ipamorelin triggers the GH pulse while CJC-1295 amplifies and extends it. The combination produces a larger, more sustained GH release than either peptide alone.
CJC-1295 (no DAC)
5mgGHRH analog for sustained GH release
Ipamorelin
5mgSelective GHRP for clean GH pulse
Mechanism of Action
How CJC-1295 Works in Your Body
Peptide Administered
Enters bloodstream via subcutaneous injection
Pituitary Activation
Stimulates the pituitary gland to release GH
GH Pulse
Natural growth hormone pulse is amplified
Tissue Response
Muscles repair, bones strengthen, fat reduces
Benefits & Side Effects
Potential Benefits
- Increased growth hormone levels
- Improved body composition (muscle gain, fat loss)
- Enhanced sleep quality
- Faster recovery from training
- Anti-aging effects (skin, energy, etc.)
- Improved bone density over time
Potential Side Effects
- Water retention (initial)
- Tingling or numbness (transient)
- Fatigue (initial as body adjusts)
- Headache (rare)
- Injection site reactions
How to store it
- Lyophilized: Refrigerate or freeze.
- Reconstituted: Refrigerate at 2-8°C; use within 4-6 weeks.
- Protect from light and heat.
Good to know
- Take on empty stomach (2+ hours after eating, 30+ min before eating).
- Bedtime dose coincides with natural GH pulse during sleep.
- This is CJC-1295 WITHOUT DAC (no Drug Affinity Complex) for daily dosing.
- Ipamorelin is the cleanest GHRP - no hunger or cortisol spike.
- Results build over 4-12 weeks (GH effects are gradual).
- Cycle 8-12 weeks on, 4-8 weeks off to prevent desensitization.
Community Insights
Summarised from 3 sourcesThe most popular growth hormone secretagogue blend combining CJC-1295 (GHRH analog) and Ipamorelin (GHRP). This combination maximizes GH release by stimulating both the GHRH and ghrelin pathways while maintaining a favorable safety profile with minimal hunger or cortisol increase. Gold standard GH p
Common Dosages Reported
- 100-300mcg each 1-2x daily
- Standard protocol dosing
Side Effects Mentioned
- Generally mild, individual variation expected
- See full guide for detailed safety info
Stacking Suggestions
- Consult research and healthcare provider before stacking
What people are saying
Results vary based on individual response
Consistent dosing and timing important
Reviews & Discussion
Real experiences shared by the community — not medical advice.
CJC-1295 and Ipamorelin Stacking Benefits
A user inquired about the benefits of stacking CJC-1295 with other compounds. Several experienced members responded by recommending the common stack with Ipamorelin to maximize growth hormone secretion and improve results compared to using CJC-1295 alone.
CJC/Ipamorelin for Weight Loss and Maintenance
A forum member shared their protocol for using a CJC-1295 and Ipamorelin blend alongside AOD-9604. They reported that combining these peptides was beneficial for weight loss and muscle maintenance after discontinued use of other performance-enhancing substances.
Absence of side effects in some users
One user reported that their subject utilized a stack of CJC-1295 and a GHRP three times daily across various dosages without ever experiencing flushing or head pressure.
Long-term experience with CJC/Ipamorelin stack
A user reported that they find CJC-1295 and Ipamorelin to be highly effective, having used the combination over ten times. While they found it beneficial for recovery and mitigating side effects of other substances, they noted it did not provide a noticeable boost to energy or drive.
CJC-1295 'Flush' side effect
A user described experiencing an immediate 'flush' sensation and head pressure shortly after injecting CJC-1295. These symptoms, which made the user feel unwell, typically subsided within 15 to 20 minutes.
Vivid dreams and flushing with CJC-1295
A user noted that while they experienced a temporary facial flush after CJC-1295 injections, they also experienced vivid dreams while using the peptide.
Positive Experience with Euphoric Side Effect
A user reported using a 200mcg/200mcg blend of CJC-1295 and Ipamorelin. They noted a positive experience, specifically enjoying a transient, moderate euphoric head rush shortly after administration.
Flushing Sensation and Nighttime Dosing
A user shared their protocol for a 5mg/5mg blend, noting that a subcutaneous injection typically produces a flushing sensation within minutes. They recommended starting with low doses between 100-300mcg before bed for best results.
Rapid Fat Loss and Lipolysis with Tesamorelin/Ipamorelin
A user described a positive experience using a combination of Tesamorelin and Ipamorelin while on a two-week diet. They reported significant lipolysis and a rapid loss of weight, which they attributed primarily to water loss, suggesting the protocol was effective for their fat loss goals.
Allergic-Type Reactions and Flushing with CJC/Ipa
A user reported adverse reactions when using a low dose of CJC-1295, both with and without Ipamorelin. Their symptoms included facial flushing and the development of hives, leading them to seek alternatives like Tesamorelin.
Water Retention and Nerve Tingling from Secretagogues
A user noted that secretagogues, including CJC-1295 and Ipamorelin variants, caused them significant unwanted side effects. Specifically, they experienced heavy water retention and uncomfortable 'tingly/numb' hands (carpal tunnel-like symptoms).
Improved Recovery and Skin Quality
A user reported positive effects on skin quality and muscle recovery while using the blend. They noted a minor side effect of experiencing a temporary hot flash or flushing sensation after administration.
Positive Initial Product Impression
A user shared their initial impressions of receiving the peptide blend, noting that the product arrived earlier than expected and was professionally packaged. They expressed confidence in the legitimacy of the product's appearance, though they did not detail specific physiological effects.
Deep Sleep Improvement with CJC-1295 and Ipamorelin
A user recommended the CJC-1295 and Ipamorelin combination specifically for its efficacy in improving sleep quality. They reported that the blend allowed them to experience deeper sleep than ever before.
Positive Review of Growth Hormone Secretagogues
The user reviewed Ipamorelin and CJC-1295 (Mod-GRF) as underrated peptides that effectively assist the body in secreting growth hormone. They characterized the substances as high-quality and beneficial pharmaceutical tools.
Muscle Growth vs. General Well-being
A user noted that while the CJC-1295 and Ipamorelin stack provided some minor assistance with muscle growth, the more significant benefits were observed in other areas such as improved sleep quality and overall body recovery. They indicated that the physiological improvements beyond muscle mass were the most notable effects after long-term use.
Lack of Discernible Effects After Two Months
After two months of administering a 5mg/5mg blend twice daily at 8 units per dose, a user reported being unable to discern any noticeable changes or benefits. They expressed uncertainty regarding whether the protocol was effective for their goals.
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