CJC-1295 DAC + Ipamorelin Stack (5mg/5mg) dosing guide
The gold standard GH optimization stack combining long-acting CJC-1295 DAC (GHRH) with Ipamorelin (GHRP). This synergistic combination maximizes growth hormone release through complementary pathways: CJC provides sustained GHRH stimulation while Ipamorelin triggers pulsatile release.
GH Release Cycle
Secretagogues trigger pulsatile growth hormone release from the pituitary.
Quickstart Highlights
- Dosage: CJC: 1-2mg/wk | Ipa: 200-300mcg/day
- Frequency: CJC: 2x/week | Ipa: Daily (bedtime)
- Administration: Subcutaneous injection
- Cycle length: 12-24 weeks
Dosing Plan
| Weeks | Dose | Units |
|---|---|---|
| Weeks 1–4 | CJC 1mg 2x/wk + Ipa 200mcg nightly | CJC: 20 units 2x/wk | Ipa: 8 units nightly |
| Weeks 5–12 | CJC 1mg 2x/wk + Ipa 300mcg nightly | CJC: 20 units 2x/wk | Ipa: 12 units nightly |
| Weeks 13–24 | CJC 1.5mg 2x/wk + Ipa 300mcg nightly | CJC: 30 units 2x/wk | Ipa: 12 units nightly |
How to mix
- CJC-1295 DAC (5mg): Add 1mL BAC water → 5mg/mL (500mcg/0.1mL).
- Ipamorelin (5mg): Add 2mL BAC water → 2.5mg/mL (250mcg/0.1mL).
- Inject slowly down vial wall.
- Swirl gently until dissolved.
- Label with date and concentration.
- Refrigerate at 2–8°C.
Syringe Math Reference
- CJC-1295 DAC (5mg/mL): 1mg = 20 units, 1.5mg = 30 units, 2mg = 40 units
- Ipamorelin (2.5mg/mL): 200mcg = 8 units, 250mcg = 10 units, 300mcg = 12 units
What you'll need
CJC-1295 DAC Vials (5mg)
- 4 weeks 2 vials
- 12 weeks 5-6 vials
Ipamorelin Vials (5mg)
- 4 weeks 2 vials
- 12 weeks 5-6 vials
Insulin Syringes (U-100)
- 4 weeks 36 syringes
- 12 weeks 100 syringes
Bacteriostatic Water (10mL)
- 12 weeks 2-3 bottles
How This Works
CJC-1295 with DAC (Drug Affinity Complex) binds to albumin in the blood, extending its half-life to approximately 8 days. It provides sustained GHRH receptor activation, elevating baseline GH production. Ipamorelin is a ghrelin mimetic that triggers pulsatile GH release through GHSR activation. When combined, the GHRH (CJC) amplifies the response to GHRP (Ipamorelin), creating synergistic GH elevations greater than either peptide alone.
CJC-1295 DAC
5mg vialLong-acting GHRH with Drug Affinity Complex for extended half-life
Ipamorelin
5mg vialSelective GHRP for clean GH pulses without side effects
Mechanism of Action
How CJC-1295 Works in Your Body
Peptide Administered
Enters bloodstream via subcutaneous injection
Pituitary Activation
Stimulates the pituitary gland to release GH
GH Pulse
Natural growth hormone pulse is amplified
Tissue Response
Muscles repair, bones strengthen, fat reduces
Benefits & Side Effects
Potential Benefits
- Significantly elevated GH and IGF-1
- Improved body composition
- Enhanced recovery from exercise
- Better sleep quality and depth
- Anti-aging effects (skin, hair, energy)
- Fat loss with muscle preservation
- Improved mood and cognitive function
Potential Side Effects
- Water retention initially
- Numbness or tingling (carpal tunnel-like)
- Increased hunger (mild)
- Fatigue or lethargy initially
- Injection site reactions
How to store it
- CJC-1295 DAC: More stable due to DAC; refrigerate reconstituted.
- Ipamorelin: Refrigerate; use within 3-4 weeks reconstituted.
- Both lyophilized: Store refrigerated or frozen.
Good to know
- CJC-1295 DAC has ~8-day half-life; 2x weekly dosing maintains steady GHRH levels.
- Ipamorelin on empty stomach at bedtime maximizes natural GH pulse.
- Do NOT eat 2 hours before Ipamorelin (insulin blunts GH release).
- This is a synergistic combination - GHRH + GHRP > either alone.
- Effects become noticeable after 4-6 weeks typically.
- Best combined with adequate sleep, exercise, and protein intake.
Community Insights
Summarised from 3 sourcesThe gold standard GH optimization stack combining long-acting CJC-1295 DAC (GHRH) with Ipamorelin (GHRP). This synergistic combination maximizes growth hormone release through complementary pathways: CJC provides sustained GHRH stimulation while Ipamorelin triggers pulsatile release. Most popular GH
Common Dosages Reported
- CJC: 1-2mg/wk | Ipa: 200-300mcg/day CJC: 2x/week | Ipa: Daily (bedtime)
- Standard protocol dosing
Side Effects Mentioned
- Generally mild, individual variation expected
- See full guide for detailed safety info
Stacking Suggestions
- Consult research and healthcare provider before stacking
What people are saying
Results vary based on individual response
Consistent dosing and timing important
Reviews & Discussion
Real experiences shared by the community — not medical advice.
Effective HGH Alternative for Growth Hormone Elevation
A user reported using CJC-1295 DAC and Ipamorelin to effectively keep their growth hormone levels and IGF-1 elevated. They found this stack to be a cheaper and more accessible alternative to pharmaceutical HGH for maintaining high-normal growth hormone levels.
Personal Success Protocol with Growth Hormone Secretagogues
A user included CJC-1295 DAC and Ipamorelin as a core part of their extensive personal success regimen for health and longevity. They used the stack specifically to maximize growth hormone levels, describing the combination as part of a high-performance protocol.
Fat Loss and Improved Sleep with CJC-1295 and Ipamorelin Stack
A user documented a detailed peptide cycle involving CJC-1295 and Ipamorelin, noting that the combination provided significant fat loss and improved sleep quality. They emphasized that Ipamorelin was effective for promoting GH release without the extreme hunger or prolactin issues associated with other peptides.
Significant IGF-1 Increase and Fat Loss with CJC/Ipamorelin Stack
A 52-year-old user reported that a 1:1 stack of CJC-1295 (No DAC) and Ipamorelin (100mcg of each, three times daily) increased their IGF-1 levels from 227 ng/ml to 406 ng/ml. They noted significant fat loss, increased musculature, and deep sleep with vivid dreams without the bloat or hunger associated with other secretagogues. The user preferred this stack over MK-677, claiming it maintained effectiveness indefinitely and felt like 'the GH and IGF-1 of an 18-year-old.'
Repeated Success for Recovery with CJC and Ipamorelin
A user shared that they have run various forms of CJC with either Ipamorelin or GHRP-6 at least ten times and found the combinations very effective for recovery. While they did not notice a significant boost in energy or mental drive, they overall 'loved' the CJC/Ipamorelin combination. They also suggested the stack could potentially mitigate some of the negative side effects found in GLP-1 medications.
Stacking CJC-1295 DAC with Ipamorelin for TRT Support
A user transitioning to growth hormone peptides expressed interest in combining CJC-1295 with DAC and Ipamorelin, believing the combination to be significantly more effective than single-agent use. They specifically sought to use Ipamorelin to assist with LH/FSH levels while on TRT, after having negative experiences with HCG.
CJC-1295 / Ipamorelin Blend Experience
A user reported positive results using a 200/200mcg blend of CJC-1295 and Ipamorelin. They noted a transient, moderate euphoric head rush upon injection and emphasized that 100mcg is the standard saturation dose to avoid side effects like receptor desensitization.
Negative Reactions to CJC-1295/Ipamorelin Stack
A user reported experiencing negative physical reactions to CJC-1295, specifically face flushing and hives. These symptoms occurred even at very low dosages, regardless of whether the peptide was stacked with Ipamorelin.
CJC-1295 and Ipamorelin Cycle Start
A user initiated a cycle of CJC-1295 and Ipamorelin and sought advice regarding their protocol. While specifically asking for guidance, the user indicated they were actively using the stack for its growth hormone-stimulating properties.
Review of Ipamorelin and CJC-1295 Stack
A user described the combination of Ipamorelin and CJC-1295 (MOD-GRF) as highly effective and underrated tools for stimulating growth hormone secretion. They reported that these peptides provide significant benefits for physical well-being and recovery.
90 Day Update - CJC 1295/Ipamorelin
A user completed a 90-day cycle of the stack and reported significant improvements in deep sleep quality and physical recovery. They also noted a decrease in body fat and an increase in lean muscle mass, though they experienced some mild water retention during the process.
Long-term Recovery and Skin Benefits
A user who has taken the stack for an extended period noted that while it provides modest assistance with muscle growth, the most profound benefits are related to general bodily repair and skin health. They emphasized that it functions better as a recovery tool than a primary muscle-building agent.
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