This stack attacks weight loss from two directions! Tirzepatide kills your appetite and helps with blood sugar (the weekly shot), while AOD-9604 directly tells your fat cells to release their stored fat (daily). One makes you eat less, the other burns more - double the power!
Think of it like: Think of weight loss like draining a bathtub. Tirzepatide turns down the faucet (you eat less). AOD-9604 pulls the drain plug (fat gets released). Using both together empties the tub WAY faster than just turning down the faucet or just opening the drain!
GLP-1 agonist + fat-burning peptide for maximum weight loss
Appetite Regulation
Peptides mimic satiety hormones, reducing hunger signals from the brain.
Quickstart Highlights
- Dosage: Tirzepatide 2.5-15mg + AOD 300mcg
- Frequency: Tirz weekly, AOD daily
- Administration: Subcutaneous
- Cycle length: 12-24 weeks
How This Works
Tirzepatide
2.5-15mgAOD
300mcgMechanism of Action
How Weight Works in Your Body
Peptide Administered
Enters bloodstream and travels to target receptors
Brain Signaling
Binds to GLP-1 receptors in the hypothalamus
Appetite Reduced
Signals satiety — you feel full sooner
Fat Metabolism
Body shifts to burning stored fat for energy
Benefits & Side Effects
Potential Benefits
- Maximum weight loss
- Appetite control
- Fat burning
- Metabolic boost
Quick notes
Start Tirzepatide low and titrate. AOD adds fat-burning without affecting GLP-1 appetite control
Community Insights
Summarised from 3 sourcesGLP-1 agonist + fat-burning peptide for maximum weight loss Start Tirzepatide low and titrate. AOD adds fat-burning without affecting GLP-1 appetite control
Common Dosages Reported
- Tirzepatide 2.5-15mg + AOD 300mcg Tirz weekly, AOD daily
- Standard protocol dosing
Side Effects Mentioned
- Generally mild, individual variation expected
- See full guide for detailed safety info
Stacking Suggestions
- Consult research and healthcare provider before stacking
What people are saying
Results vary based on individual response
Consistent dosing and timing important
Reviews & Discussion
Real experiences shared by the community — not medical advice.
Metabolism and Fat Loss Stack for CFS symptoms
A user inquired about a stack for fat loss and energy to manage being overweight while dealing with possible chronic fatigue syndrome (CFS). The proposed stack focused on increasing metabolism and providing sustained energy throughout the day.
Nicotinamide Riboside (NR) for Energy and Metabolism
Users on this thread shared personal experiences with Nicotinamide Riboside (NR), noting improvements in energy levels and metabolic health. Some reported that the supplement helped with weight management and recovery after physical exertion.
ECA Stack for Female Fat Loss
A female user inquired about the ECA stack (Ephedrine, Caffeine, Aspirin) for weight loss, and experienced members shared that it provided a potent thermogenic effect and appetite suppression. The consensus in the thread was that it is an effective 'classic' stack, though users should start with lower dosages to assess stimulant tolerance.
T3 Fat Loss Success with Exercise
A user reported significant fat loss results by utilizing T3 in conjunction with a strict diet and exercise regimen. They noted that while the substance was highly effective for leaning out, it required careful monitoring to avoid muscle wasting.
Timeline for T3 Visible Results
A forum participant discussed their experience with T3, stating that noticeable fat loss effects typically began to manifest within the second week of use. They emphasized that the speed of results heavily depended on the individual's metabolic starting point and dosage consistency.
Alpha Lean 7 and Anafuse Stack
A user reported plans to use a stack of Alpha Lean 7 and Anafuse to aid in fat loss while managing body fat around 23%. They also considered adding TR1UMPH and Alpha Max XT to support their transition between lean bulking and fat loss phases.
Synergy of Forskolin and Ephedrine
A forum member recommended adding Forskolin 95 to a weight loss stack, noting its synergistic effects with ephedrine. They suggested working up to a dose of 100mg of 95% extract daily to enhance the effectiveness of the cut.
Core Staples for Fat Loss
An experienced user highlighted that after trying numerous products, their only consistent re-purchases for fat loss are Caffeine, Ephedrine, and Yohimbine HCL, paired with a significant caloric deficit. They emphasized these as the most effective staples compared to more complex supplement formulas.
SNS Lean Edge and Support Stacks
A board sponsor recommended SNS Lean Edge as a premier stimulant-free fat burner, noting it has been ranked as a top product for over two years due to its multi-angle approach to weight loss. They suggested stacking it with newer products like Thermo Scorch or LipoVantage, particularly for those who respond well to MitoBurn.
ECA vs. YCA Cycle Transitions
A user discussed utilizing an ECA stack (Ephedrine, Caffeine, Aspirin) via Bronkaid for general weight loss, or a YCA stack (Yohimbine, Caffeine, Aspirin) for more stubborn fat. Another contributor suggested running the ECA stack for the first 4-6 weeks of a cut and transitioning to Yohimbine HCL for the final 4-6 weeks to maximize results.
Semaglutide as a Weight Loss Game Changer
Healthcare professionals discussed Semaglutide as a 'game-changer' for weight loss in a dedicated forum thread. The discussion highlighted the drug as a newly approved and highly effective solution for users seeking significant weight reduction.
Natural Thermogenic Stack for Fat Loss
A user shared their personal weight loss stack consisting of Green Coffee Bean Extract, Raspberry Ketones, L-Carnitine, CLA, and Fucothin. They reported achieving great results with this combination and highlighted it as a safer and very effective alternative to stimulant-heavy stacks.
General Efficacy and Weight Regain Concerns Following Discontinuation
A member shared that they and many others have found success using Retatrutide and Tirzepatide for weight loss. However, they cautioned that stopping the medication completely often leads to the weight returning. This suggests a potential need for long-term maintenance rather than a short-term cycle.
Retatrutide for Appetite Control and Food Discipline
A user shared that utilizing Retatrutide allowed them to move away from using a strict keto diet as a 'crutch' for weight loss. They reported that the GLP-1 agonist effectively controlled their previous carb-centric overeating and 'food fiend' behavior. The user believes the peptide is helping them build a healthier relationship with food and better discipline.
Return of Appetite and Binging After Stopping Retatrutide
A user documented a five-week break from Retatrutide after reaching a dose of 10 mg/week, aiming to resensitize to the drug. They reported that food noise and overeating urges remained absent for the first three weeks but returned strongly by week five, leading to two instances of impulsive binge eating. The user concluded that while the drug is highly effective, the psychological urges to overeat return once the medication is discontinued.
Significant Weight Loss and Improved Metabolic Markers on Retatrutide
A user reported losing 81 lbs over approximately eight months (from 391 lbs down to 310 lbs) while using Retatrutide. They noted that the peptide significantly improved their blood markers, moving them from a pre-diabetic state to the middle of the normal HbA1c range, and significantly improved their lipids. Despite reaching a 10 mg/week dosage, they were able to maintain strength and hit new personal records in the gym.
RAD-140 for Lean Mass and Fat Reduction
A user noted that RAD-140 effectively reduces body fat by facilitating the growth of lean body mass. They cautioned that fat loss occurs as long as the individual avoids an excessive caloric surplus.
ALCAR for Fat Metabolism
A user inquired about using Acetyl-L-Carnitine (ALCAR) for fat metabolism and weight loss. Discussion in the thread suggests that while it may assist with energy and fatty acid transport, its effectiveness for significant weight loss remains a subject of conflicting reports.
Prolintane and Adrafinil Stack for Weight Loss
A user reported significant success with a weight loss stack consisting of prolintane and adrafinil. However, they noted the stack caused unpleasant side effects and expressed hesitation in fully recommending it to others.
Tirzepatide Success and Stacking Inquiry
A 44-year-old female reported significant appetite reduction and weight loss success after six weeks on 5mg of Tirzepatide. She is currently exploring additional stacking options to further optimize her results.
Transitioning from Weight Loss to muscle Gain Post-50kg Loss
After successfully losing 50kg (110 lbs), a user reached out for guidance on a safe peptide stack to transition into a muscle-building phase. They are prioritizing safety while seeking to improve their physique further after substantial weight loss.
Seeking Effective Weight Loss and Muscle Retention Stack
A user looking to reach a target weight of 210-220 lbs while maintaining muscle mass sought advice on the most effective weight loss stack. They expressed interest in using peptides as a primary boost for their body recomposition goals.
Personal Experience with Nicotinamide Riboside in Metabolic Stacks
A user shared their personal experience thread regarding Nicotinamide Riboside (NR/Niagen). While primarily focused on NR, the discussion touches on its potential role in weight management and metabolic health stacking.
Inquiry into Metabolism and Fat Loss Stack for CFS symptoms
A user who is an overweight female with possible Chronic Fatigue Syndrome (CFS) sought advice on a weight loss stack. They were looking to combine various supplements and potentially peptides to improve metabolism, increase fat loss, and boost energy levels.
Female Dosing and Tolerance for ECA Stack
A female user inquired about the appropriate dosage for an ECA (Ephedrine, Caffeine, Aspirin) stack, expressing concern about over-stimulation. Other community members advised starting with a half-dose to assess tolerance due to the potent thermogenic effects.
T3 for Fat Loss and Muscle Sparing Concerns
A user shared their experience using T3 for fat loss, noting that while it was effective for reducing body fat, it also led to significant muscle loss when not paired with anabolic steroids. They emphasized the importance of a graduated dosing schedule and reported feeling increased body temperature as a primary side effect.
Timeline for T3 Visible Results
A user reported noticing visible fat loss results from T3 within 10 to 14 days of consistent use. They mentioned that the metabolic increase was apparent through a higher resting heart rate and increased perspiration during workouts.
Synergy of Forskolin and Ephedrine
A user suggested that adding Forskolin 95 to an ephedrine-based stack provides synergistic effects for weight loss. They recommended working up to a dose of 100mg per day of the 95% extract.
The Core Fundamentals: ECA and Yohimbine
An experienced user stated that after trying many different supplements, the only ones worth re-purchasing for fat loss are Caffeine, Ephedrine, and Yohimbine HCL. They emphasized that these must be combined with a 500-1000kcal caloric deficit to be effective.
Alpha Lean 7 and Anafuse Cycle
A user mentioned utilizing a combination of Alpha Lean 7 and Anafuse for a body fat reduction phase. They were planning to integrate these supplements into a cycle of "lean bulking" and "reset" phases to manage body composition.
Lean Edge and Stimulant-Free Stacking
A user highlighted Lean Edge as a premier stimulant-free fat burner, noting it has been top-ranked for over two years due to its multi-angle approach to weight loss. They suggested stacking it with other products like Thermo Scorch or LipoVantage if the user responds particularly well to ingredients like MitoBurn.
Cycling ECA and YC Stacks for Cutting
A user recommended cycling fat loss stacks by starting with ECA (Ephedrine, Caffeine, Aspirin) for the first 4-6 weeks to facilitate general weight loss. They suggested transitioning to a YC stack (Yohimbine and Caffeine) for the final 4-6 weeks to specifically target stubborn fat.
Semaglutide as a Weight Loss Solution
Medical professionals discussing Semaglutide characterized the peptide as a "game changer" for weight loss. The discussion highlights it as a potent and effective solution among newly approved weight-loss drugs.
Natural Thermogenic Weight Loss Stack
A user reported achieving great results by stacking several compounds for fat loss: Green Coffee Bean Extract, Raspberry Ketones, L-Carnitine, CLA, and Fucothin. They described this combination as safe and very effective compared to older, potentially riskier stacks like ECA.
Retatrutide for Carbohydrate Cravings and Food Discipline
A user reported using Retatrutide (and GLP-1s in general) to successfully manage a former 'fiend-like' addiction to carbohydrates and chronic overeating. They found the medication effectively replaced their reliance on a strict keto diet as a 'crutch' for weight control. The user noted that the peptide provided the discipline needed to build a healthier relationship with food while progressing in strength training.
Significant Weight Loss and Improved HbA1c on Retatrutide
A user reported losing 81 lbs (from 391 lbs to 310 lbs) over approximately eight months using Retatrutide, reaching a maximum dose of 10 mg/week. They noted significant improvements in health markers, including moving from pre-diabetic to a normal HbA1c range and better lipid profiles. After stopping the peptide for five weeks to resensitize, they observed that appetite suppression lasted about three weeks, after which overeating urges and impulsive binging returned.
Reflections on Weight Regain After Stopping Peptides
A user who has used weight loss peptides successfully cautioned that weight regain is likely if the medication is stopped completely. They suggest that continued use or a maintenance strategy may be necessary to sustain results.
RAD-140 for Lean Mass and Fat Reduction
A user noted that RAD-140 can effectively lower body fat percentages by facilitating the growth of lean body mass. They emphasized that fat loss occurs as long as the user avoids an excessive caloric surplus while on the cycle.
Prolintane and Adrafinil Stack for Weight Loss
A user reported finding success with a stack of prolintane and adrafinil for weight loss and dieting. However, they noted that the combination caused some unpleasant side effects, making it difficult to fully recommend.
ALCAR for Fat Metabolism Inquiry
A user inquired about the efficacy of Acetyl-L-Carnitine (ALCAR) for fat metabolism and weight loss. They noted conflicting information in literature regarding whether ALCAR provides the same fat-burning benefits as standard L-carnitine.
Post-Weight Loss Muscle Gain Stack
After successfully losing 110 lbs, a user inquired about safe peptide stacks specifically designed for muscle gain and body recomposition. Their focus shifted from active weight loss to maintaining their weight while improving muscle definition and recovering from significant weight reduction.
Weight Loss and Muscle Retention Goal
A user expressed interest in using a peptide stack to facilitate weight loss with the goal of reaching a target weight of 210-220 lbs while maintaining muscle mass. They sought recommendations for combining fat-burning peptides with those that support metabolic health.
Tirzepatide for Appetite Suppression and Weight Loss
A 44-year-old female user reported significant appetite reduction and weight loss while taking 5mg of Tirzepatide. She sought advice on stacking additional peptides to address low energy levels and stalled progress after the initial six weeks of treatment.
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