Melanotan II + PT-141 Stack dosing guide
A melanocortin receptor stack combining Melanotan II (tanning and libido) with PT-141/Bremelanotide (sexual function). Both act on melanocortin receptors but PT-141 is more selective for sexual effects while MT-II also provides tanning benefits.
Hormonal Response
Acts on melanocortin pathways to support libido and sexual function.
Quickstart Highlights
- Dosage: MT-II: 0.5-1mg | PT-141: 1-2mg
- Frequency: MT-II: 2-3x/week | PT-141: As needed
- Administration: Subcutaneous injection
- Cycle length: 4-8 weeks (tanning) | PT-141 as needed
Dosing Plan
| Weeks | Dose | Units |
|---|---|---|
| MT-II Loading (Week 1) | MT-II 0.25mg daily | 25 units daily |
| MT-II Loading (Week 2) | MT-II 0.5mg daily | 50 units daily |
| MT-II Maintenance (Week 3+) | MT-II 0.5-1mg 2-3x/week | 50-100 units, 2-3x weekly |
| PT-141 (As needed) | PT-141 1-2mg 2-4 hours pre-activity | 100-200 units per use |
How to mix
- Melanotan II (10mg): Add 10mL BAC water → 1mg/mL concentration.
- PT-141 (10mg): Add 10mL BAC water → 1mg/mL concentration.
- Inject slowly, swirl gently.
- Label and refrigerate at 2–8°C.
Syringe Math Reference
- MT-II (1mg/mL): 0.25mg = 25 units, 0.5mg = 50 units, 1mg = 100 units
- PT-141 (1mg/mL): 1mg = 100 units, 1.5mg = 150 units, 2mg = 200 units
What you'll need
Melanotan II Vials (10mg)
- 4 weeks (loading + maintenance) 1-2 vials
- 8 weeks 2 vials
PT-141 Vials (10mg)
- As needed 1 vial (5-10 uses)
Insulin Syringes (U-100)
- 8 weeks 30-50 syringes
Bacteriostatic Water (10mL)
- 8 weeks 2 bottles
How This Works
Both peptides are melanocortin receptor agonists. Melanotan II activates MC1R (melanogenesis/tanning), MC3R, and MC4R (appetite, sexual function). PT-141 is more selective for MC3R and MC4R, which mediate sexual arousal through central nervous system pathways independent of the vascular system. Unlike PDE5 inhibitors (Viagra), these work through brain pathways to enhance desire and arousal.
Melanotan II
10mg vialNon-selective melanocortin agonist for tanning and libido enhancement
PT-141 (Bremelanotide)
10mg vialMC3R/MC4R agonist specifically for sexual dysfunction treatment
Mechanism of Action
How Melanotan Works in Your Body
Peptide Administered
Enters systemic circulation
CNS Activation
Acts on melanocortin receptors in the brain
Hormone Cascade
Triggers downstream hormonal signaling
Response
Enhanced libido and sexual function
Benefits & Side Effects
Potential Benefits
- Accelerated tanning (MT-II)
- Enhanced libido in both sexes
- Improved erectile function (men)
- Enhanced arousal and desire (women)
- Appetite suppression (MT-II)
- Potential UV protection from increased melanin
Potential Side Effects
- Nausea (common, especially initially with MT-II)
- Facial flushing
- Fatigue
- Headache (PT-141)
- Increased mole pigmentation
- Spontaneous erections (MT-II)
- Nasal congestion (PT-141)
How to store it
- Both peptides: Refrigerate after reconstitution at 2–8°C.
- Melanotan II: Relatively stable; use within 4-6 weeks.
- PT-141: Use within 4 weeks reconstituted.
- Can freeze aliquots for longer storage.
Good to know
- Start MT-II at low dose to assess tolerance (nausea common initially).
- Take MT-II before bed - nausea usually occurs within 1-2 hours.
- MT-II causes tanning even without sun, but UV exposure accelerates it.
- MT-II may darken moles - monitor existing moles for changes.
- PT-141 works 2-4 hours after injection; effects last 6-12 hours.
- PT-141 is FDA-approved (Vyleesi) for female HSDD.
- Do not use PT-141 more than 8 times per month (FDA guidance).
Community Insights
Summarised from 3 sourcesA melanocortin receptor stack combining Melanotan II (tanning and libido) with PT-141/Bremelanotide (sexual function). Both act on melanocortin receptors but PT-141 is more selective for sexual effects while MT-II also provides tanning benefits. MT-II for base tan and libido; PT-141 specifically for
Common Dosages Reported
- MT-II: 0.5-1mg | PT-141: 1-2mg MT-II: 2-3x/week | PT-141: As needed
- Standard protocol dosing
Side Effects Mentioned
- Generally mild, individual variation expected
- See full guide for detailed safety info
Stacking Suggestions
- Consult research and healthcare provider before stacking
What people are saying
Results vary based on individual response
Consistent dosing and timing important
Reviews & Discussion
Real experiences shared by the community — not medical advice.
Selective Receptor Activation with MT-II and PT-141
A user described using Melanotan II and PT-141 for their effects on melanocortin receptors. They noted that while Melanotan II is effective for tanning (MC1R) and libido, PT-141 is more selective for the MC4R receptor, providing similar pro-sexual benefits with less effect on skin pigmentation.
Potent Libido Enhancement from MT-II and PT-141 Stack
A user shared their experience with a combination of Melanotan II and PT-141, reporting a significant increase in libido and erectile function. They highlighted that the stack was highly effective for 'libido enhancement' but cautioned about potential nausea if the dosage is too high.
Comparison of PT-141 and Melanotan II Effects
A user shared that while PT-141 provides a significant boost to libido and sexual function, it is essentially a metabolite of Melanotan II. They noted that Melanotan II offers similar pro-sexual benefits along with tanning effects, whereas PT-141 is more focused specifically on sexual desire and arousal.
Synergistic Effects of PT-141 and MT2 Stack
A user reported that combining PT-141 with Melanotan II (MT2) resulted in a very potent synergetic effect on libido. They described the experience as providing 'uncontrollable' sexual desire and extremely persistent physical arousal for several hours.
Nausea and Flushing Side Effects
A user noted that while the combination of these peptides is effective for libido, the initial side effects can be unpleasant. They reported experiencing significant nausea and facial flushing shortly after administration before the positive effects began.
Melanotan II for Cycle-Induced Libido Loss
A user attempted to treat a flatlined libido caused by a Trenbolone and Testosterone cycle using Melanotan II. They started with a cautious dose of 300mcg to avoid potential severe nausea and vomiting before planning to move to 500mcg.
Erection Benefits vs. Libido and Side Effects
A forum member cautioned that Melanotan II is ineffective for increasing actual sexual desire or libido, though it is successful at inducing temporary physical erections. They noted the peptide is notorious for causing significant stomach cramps and nausea at doses around 500mcg.
Melanotan II in Performance Stacking
A user recommended Melanotan II as part of a 'Pornstar Supplement Stack' designed to improve sexual performance and physical function. They suggested it can be combined with other compounds like Clomid and HCGenerate for peak performance during a specific weekend.
PT-141 for Libido and Erections
A user reported that 1 mg of PT-141 led to a slightly increased libido and a partial erection lasting approximately 14 hours. Increasing the dose to 1.25 mg combined with TRT resulted in a dramatic libido surge and powerful, youthful erections peaking 5 hours after injection.
Melanotan II for Libido and Appetite Suppression
A user experienced immediate facial flushing and strong stomach cramps after an initial 0.5 mg dose of Melanotan II. While they noted effective appetite suppression and a minor 15% boost in libido, they did not experience the significant random erections reported by others.
PT-141 for Sexual Desire and Drive
A user shared that while Trimix helps with physical performance, they use PT-141 specifically to increase sexual urge and desire. They found that PT-141 successfully addresses the mental aspect of libido that other treatments like Trimix or TRT sometimes fail to stimulate.
Melanotan II and PT-141 for Libido Enhancement
A user recommended Melanotan II as an effective non-steroidal option for improving erections and libido. Another participant noted that PT-141 is the specific 'sex-related' component of the Melanotan II molecule.
PT-141 and Oxytocin Stack
A user reported that combining PT-141 with a small amount of oxytocin produced excellent results for sexual performance and partner satisfaction. They described the combination as being very effective.
High-Dose PT-141 Performance Stack
A member detailed a 'date night' protocol that includes 4mg of PT-141 alongside Cialis, Viagra, and various anabolic steroids. The user implied the stack is extremely potent for sexual performance, humorously suggesting it leads to physical damage to the room from intense activity.
Melanotan II Skin Pigmentation and Lack of Sexual Effects
A user reported that repeated use of Melanotan II in combination with a tanning bed resulted in permanently darker skin. Despite the common association of these peptides with libido enhancement, the user noted that they did not experience any sexual side effects from either Melanotan II or PT-141.
Comparison of PT-141 and MT2 for Libido
A user compared the two peptides, noting that PT-141 is more convenient for targeted use but Melanotan II provides longer-lasting and more consistent results. They specifically recommended PT-141 for those seeking the highest increase in libido.
Overdosage Experience with Melanotan II
A user shared a cautionary experience regarding excessive dosage of Melanotan II. They reported seeking a starter dose of 250mcg and ramping up to 500-1000mcg daily, which they later characterized as an error in judgment due to taking far too much.
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