Ipamorelin + Tesamorelin (10mg Blend) dosing guide
This is a premium GH blend! Tesamorelin is special because it's actually FDA-approved for reducing belly fat (visceral fat). Combined with clean Ipamorelin, you get powerful GH release that especially targets that stubborn fat around your organs.
Think of it like: Think of Tesamorelin as a specialized fat-burning sniper that targets the dangerous fat around your belly and organs. Ipamorelin is like backup support that makes everything work better. Together, they're particularly good at attacking that hard-to-lose midsection fat!
This blend combines tesamorelin, a synthetic GHRH analog, with ipamorelin, a selective ghrelin mimetic. When administered together, GHRH analogs and ghrelin mimetics produce synergistic GH pulses. Tesamorelin is FDA-approved for visceral fat reduction.
GH Release Cycle
Secretagogues trigger pulsatile growth hormone release from the pituitary.
Quickstart Highlights
- Dosage: 250-2000mcg Tesa + 125-1000mcg Ipa
- Frequency: Daily
- Administration: Subcutaneous
- Cycle length: 12-26 weeks
Dosing Plan
| Weeks | Dose | Units |
|---|---|---|
| Weeks 1–2 | 250mcg Tesa + 125mcg Ipa daily | 15 units (0.15mL) |
| Weeks 3–8 | 1000mcg Tesa + 500mcg Ipa daily | 60 units (0.60mL) |
| Weeks 9–26 | 2000mcg Tesa + 1000mcg Ipa daily | 120 units (1.2mL) - may need larger syringe |
How to mix
Add 3.0mL bacteriostatic water → ~3.33mg/mL total (1.67mg/mL each)
- Draw 3.0mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall.
- Gently roll until dissolved (do not shake).
- Label with date and refrigerate at 2–8°C.
Syringe Math Reference
- 10mg vial with 3mL BAC water = 3.33 mg/mL total
- Each peptide: 1.67 mg/mL
- 1 unit = 0.01mL ≈ 16.7mcg of each peptide
- 250mcg Tesa = 15 units
- 1000mcg Tesa = 60 units
- 2000mcg Tesa = 120 units
What you'll need
Blend Vials (10mg)
- 4 weeks 4-6 vials
- 12 weeks 12-18 vials
- 26 weeks 26-40 vials
Insulin Syringes (U-100, 1mL)
- 4 weeks 30 syringes
- 26 weeks 200 syringes
Bacteriostatic Water (10mL)
- 26 weeks 8-10 bottles
Alcohol Swabs
- 26 weeks 4 × 100-count boxes
How This Works
Tesamorelin is a modified GHRH analog that stimulates pituitary GH release with enhanced stability. Ipamorelin is a ghrelin mimetic that triggers GH secretion through a complementary pathway. Together, they produce synergistic GH pulses. Tesamorelin specifically targets visceral fat through GH-mediated lipolysis.
Tesamorelin
5mgFDA-approved GHRH analog for visceral fat reduction
Ipamorelin
5mgSelective GH secretagogue for synergistic effects
Mechanism of Action
How Ipamorelin Works in Your Body
Peptide Administered
Enters bloodstream via subcutaneous injection
Pituitary Activation
Stimulates the pituitary gland to release GH
GH Pulse
Natural growth hormone pulse is amplified
Tissue Response
Muscles repair, bones strengthen, fat reduces
Benefits & Side Effects
Potential Benefits
- Synergistic GH release
- Significant visceral fat reduction
- Improved body composition
- Potential cognitive benefits
- Enhanced sleep quality
Potential Side Effects
- Injection site reactions
- Joint pain
- Peripheral edema
- Elevated blood glucose (monitor if diabetic)
How to store it
- Lyophilized: Refrigerate at 2–8°C.
- Reconstituted: Refrigerate; use immediately or within 24 hours (tesamorelin less stable).
Good to know
- Tesamorelin is FDA-approved for visceral fat reduction.
- Synergistic GH release from GHRH + GHRP combination.
- Premium stack for body composition.
- Higher vial consumption due to higher tesamorelin doses.
- May have cognitive benefits (tesamorelin effect).
Community Insights
Summarised from 3 sourcesThis blend combines tesamorelin, a synthetic GHRH analog, with ipamorelin, a selective ghrelin mimetic. When administered together, GHRH analogs and ghrelin mimetics produce synergistic GH pulses. Tesamorelin is FDA-approved for visceral fat reduction. Tesamorelin is FDA-approved. Premium blend for
Common Dosages Reported
- 250-2000mcg Tesa + 125-1000mcg Ipa Daily
- Standard protocol dosing
Side Effects Mentioned
- Generally mild, individual variation expected
- See full guide for detailed safety info
Stacking Suggestions
- Consult research and healthcare provider before stacking
What people are saying
Results vary based on individual response
Consistent dosing and timing important
Reviews & Discussion
Real experiences shared by the community — not medical advice.
Significant IGF-1 Increase with CJC/Ipamorelin Blend
A user reported that switching to a 10mg blend of CJC-1295 (no DAC) and Ipamorelin resulted in a significant increase in IGF-1 levels, nearly doubling their baseline. They administered three shots daily and experienced no side effects, noting the results were superior to those they achieved with MK-677.
Effective for Recovery over Multiple Cycles
A user reported positive experiences using a CJC-1295 and Ipamorelin combination across at least ten different cycles, noting its effectiveness for recovery. However, they mentioned that the stack did not provide a noticeable boost to energy or drive.
Intense Heat Flush and Increased Heart Rate
A user experienced a 'CJC flush' after administering a 600 mcg dose, characterized by an immediate sensation of intense heat, increased heart rate, and altered breathing. Other members confirmed this is a common, dose-dependent side effect of the peptide.
Experience with CJC-1295/Ipamorelin Blend Euphoria
A user shared personal experience using a CJC-1295 and Ipamorelin blend at a dosage of 200mcg of each component. They noted enjoying a transient, moderate euphoric head rush following administration.
Flushing Response and Timing for Ipamorelin/CJC-1295
A user reported that when using an Ipamorelin/CJC-1295 blend, a flushing sensation should typically occur within minutes of a subcutaneous injection. They recommended starting with the lowest possible dose, generally between 100mcg and 300mcg before bed.
High Efficacy for Fat Loss and Anabolic Effects
A user reported that the combination of Tesamorelin and Ipamorelin has been highly effective for fat loss and lipolysis while on a diet. They described themselves as a hyper-responder, noting that the stack feels anabolic and has led to a significant loss of water weight and fat within two weeks.
Excessive IGF-1 and Side Effects at 2mg Dose
A user found that 2mg of Tesamorelin was too potent, mirroring their negative experiences with HGH. They reported that GH-stimulating compounds raised their IGF-1 levels excessively, leading to ruined sleep, carpal tunnel syndrome, and premature facial aging.
Significant IGF-1 Increase over Two Months
A user reported that 2mg of Tesamorelin taken nightly for two months successfully raised their IGF-1 levels from a baseline of 243 to 357. They noted that it effectively stimulated growth hormone production without reaching the extreme levels seen with high-dose generic HGH.
Improved Sleep and Minor Site Reactions
One individual experienced improved sleep while using Tesamorelin, though they noted minor injection site pain (PIP) and local skin reactions. They emphasized that the peptide requires long-term use to see significant results for goals like visceral fat reduction.
Severe Anaphylactic Shock and Escalating Sensitivity
A user experienced a severe anaphylactic reaction after injecting a combination of CJC, Ipamorelin, and Tesamorelin, including hives, shortness of breath, and loss of consciousness. They noted that their sensitivity escalated over time, moving from minor flushing in previous cycles to a life-threatening emergency.
Tesamorelin/Ipamorelin Blend for Fat Loss
A user reported highly positive results using a Tesamorelin and Ipamorelin blend taken at night on an empty stomach. They noted that the combination was extremely effective at reducing abdominal fat, resulting in a flat stomach for the first time.
Inquiry on Healing Shoulder Injury with Tesa/Ipa
A user inquired about using a Tesamorelin and Ipamorelin blend specifically to help heal a chronic shoulder injury. They expressed interest in the synergistic effects of the combination for recovery rather than just fat loss.
Short-Term Stack for Fat Loss
A user considered stacking Tesamorelin with Ipamorelin for a short one-month cycle to address abdominal fat. They questioned whether continuing Ipamorelin solo after the Tesamorelin month would better maintain any body composition results achieved.
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