HCG (Human Chorionic Gonadotropin) dosing guide
LH analog for testicular function, fertility, and testosterone support during TRT
Endocrine Signaling
Hormonal peptides modulate release along the endocrine axis.
Quickstart Highlights
- Dosage: 250-500iu
- Frequency: 2-3x weekly
- Administration: Subcutaneous or intramuscular
- Cycle length: Ongoing during TRT
Dosing Plan
| Weeks | Dose | Units |
|---|---|---|
| Standard TRT Adjunct | 250iu 2-3x weekly | 10 units (0.1mL) from 2,500iu/mL |
| Enhanced plan | 500iu 2-3x weekly | 20 units (0.2mL) |
| Fertility plan | 1000-2000iu 2-3x weekly | Higher doses for spermatogenesis |
| PCT | 1000-1500iu EOD for 2-3 weeks | Taper down over time |
How to mix
2ml BAC water per 5000iu vial
- Draw 2.0mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall - HCG is delicate.
- Gently swirl (NEVER shake) until completely dissolved.
- Label with date. Concentration = 2,500iu/mL.
- Refrigerate at 2–8°C immediately. Use within 30 days.
Syringe Math Reference
- 5000iu vial with 2mL BAC water = 2,500 iu/mL
- 250iu dose = 10 units (0.1mL)
- 500iu dose = 20 units (0.2mL)
- 1000iu dose = 40 units (0.4mL)
- 10000iu vial with 2mL = 5,000iu/mL; 250iu = 5 units (0.05mL)
What you'll need
HCG Vials (5000iu)
- 4 weeks (250iu 3x/wk) 1 vial
- 8 weeks 1-2 vials
- 12 weeks 2-3 vials
Insulin Syringes (U-100)
- 4 weeks 12 syringes
- 8 weeks 24 syringes
- 12 weeks 36 syringes
Bacteriostatic Water (10mL)
- Per vial 1 bottle
- 8 weeks 1 bottle
- 12 weeks 1 bottle
Alcohol Swabs
- 4 weeks 1 × 100-count box
- 8 weeks 1 × 100-count box
- 12 weeks 1 × 100-count box
How This Works
HCG (Human Chorionic Gonadotropin) structurally mimics luteinizing hormone (LH) and binds to LH receptors on testicular Leydig cells. This stimulates intratesticular testosterone production and maintains spermatogenesis. During TRT, exogenous testosterone suppresses natural LH production, causing testicular atrophy and infertility. HCG replaces the missing LH signal, preserving testicular size, function, and fertility.
Mechanism of Action
How HCG Works in Your Body
Peptide Administered
Enters the bloodstream via injection
Receptor Binding
Finds and activates its target receptor
Signal Cascade
Triggers a chain of cellular responses
Biological Effect
The body produces the desired outcome
Benefits & Side Effects
Potential Benefits
- Maintains testicular size during TRT
- Preserves fertility and spermatogenesis
- Supports intratesticular testosterone production
- Prevents testicular atrophy
- Decades of clinical use and safety data
- Essential for PCT (Post-Cycle Therapy)
Potential Side Effects
- Estrogen conversion at higher doses
- Water retention
- Mood changes
- Gynecomastia (if estrogen not managed)
- Injection site irritation
- Rare: headache
How to store it
- Lyophilized: Store refrigerated at 2–8°C (do NOT freeze).
- Reconstituted: Refrigerate at 2–8°C; use within 30 days.
- HCG is temperature-sensitive - avoid room temperature storage.
- Protect from light. Do not freeze.
Good to know
- Gold standard for maintaining testicular function during TRT.
- Mimics LH to directly stimulate Leydig cells for testosterone and sperm production.
- Availability has become limited in some regions - Gonadorelin is an alternative.
- Must be refrigerated at all times - more temperature-sensitive than most peptides.
- Higher doses (1000iu+) needed for fertility plans vs. maintenance (250-500iu).
- Can cause estrogen conversion at higher doses - may need an AI.
- Regular blood work recommended to monitor estradiol and testosterone levels.
Community Insights
Summarised from 3 sourcesLH analog for testicular function, fertility, and testosterone support during TRT Standard for TRT fertility maintenance. Higher doses (1000+ iu) for fertility plans
Common Dosages Reported
- 250-500iu 2-3x weekly
- Standard protocol dosing
Side Effects Mentioned
- Generally mild, individual variation expected
- See full guide for detailed safety info
Stacking Suggestions
- Consult research and healthcare provider before stacking
What people are saying
Results vary based on individual response
Consistent dosing and timing important
Reviews & Discussion
Real experiences shared by the community — not medical advice.
HCG for Hormonal Recovery
A user mentioned using hCG as a bridge to restart natural testosterone production after a period of suppression. They found it useful for restoring hormonal balance and improving general well-being during the recovery phase.
HCG and Fat Loss Skepticism
A user discussed the hCG diet protocol for fat loss but remained skeptical. They noted that weight loss likely resulted from the extreme 500-calorie restriction rather than the peptide itself, though they mentioned the peptide is claimed to prevent muscle loss and suppress appetite during the deficit.
HCG for Hormone Replacement Support
A user reported using hCG injections to manage symptoms of hypogonadism. They shared that the treatment effectively stimulated natural testosterone production and helped maintain testicular volume while on hormone replacement therapy.
HCG Timing and Protocol Discussion
Users discussed the timing of HCG administration, debating whether it is more effective when used throughout the entire cycle or reserved for the end. The consensus among many experienced users suggests that intra-cycle use helps maintain testicular function and eases the transition into post-cycle therapy.
Physical Side Effects of Long-Term HCG
A user noted that long-term use of HCG resulted in an increase in the size of their testicles and penis. They identified these physical changes as distinct side effects of extended HCG administration.
Intra-cycle HCG Use
A user reported that they choose to take HCG exclusively while on an anabolic steroid cycle to mitigate side effects. This practice is supported by a segment of the forum community, with nearly 38% of poll respondents indicating they follow a similar protocol.
Preventing Testicular Degeneration via Continuous Low-Dose Use
An experience report highlights that using a small maintenance dose of HCG throughout a steroid cycle prevents testicular degeneration and the loss of Leydig cell volume. The user emphasized that this strategy is superior to waiting until post-cycle therapy to begin treatment.
Swale Protocol for Intra-Cycle Maintenance
A user reported successfully using the 'Swale protocol' which involves low doses of 250IU to 500IU twice weekly during an anabolic steroid cycle. They noted this prevented the 'edgy, burned-out' feeling typically associated with cycles and maintained better overall daily wellbeing.
Effective Testicular Maintenance and Recovery
A member who follows the Swale protocol reported that using small amounts of HCG (250IU-500IU) twice per week from the start of a cycle is the most effective method for them. They found it effectively maintains testicular form and function, making post-cycle recovery much smoother.
HCG for Testicular Maintenance and Fertility
A user discussed research and protocols for using HCG alongside TRT to prevent testicular atrophy and maintain fertility. The suggested protocol involves doses around 500 IU to maintain intratesticular testosterone levels while on exogenous hormones.
HCG vs. HMG for Fertility Support
A user compared the differences between HCG and HMG for reproductive health, noting that while HCG mimics LH to stimulate testosterone, HMG acts more like FSH to directly support sperm production. This distinction is presented as crucial for men navigating fertility issues while on TRT.
HCG for Libido and ED Improvement on TRT
A user provided information on a clinical study showing that adding HCG to TRT significantly improves libido and erectile function compared to testosterone alone. The report highlights that HCG mimics LH, which may stimulate neurosteroids that improve sexual drive.
Dosage Optimization for Testicular Function
An expert profile highlights that shifting from high medical doses (5000 IU) to frequent low doses (sub-500 IU) reduces the drug's perceived harshness while remaining effective. The report notes that HCG is a primary tool for normalizing testicular function impaired by steroid use.
Improved Well-being and Testicular Restoration
A user who has utilized HCG for three years reported that it significantly improved their general sense of well-being. They also noted that it successfully restored and sometimes increased testicular size beyond original levels.
Managing E2 Elevation with HCG
A long-term user cautioned that HCG can increase E2 (estrogen) levels, which may complicate its use alongside testosterone. They suggested that some users may need to cycle between testosterone and HCG or utilize frequent, low-dose injections to manage this side effect.
HCG as a Test Base
A forum member discussed using HCG as a test base, describing it as a Luteinizing Hormone (LH) mimetic. However, they noted it is typically less effective than other solutions and cautioned that it can suppress natural function if used incorrectly.
HCG for Testicular Maintenance
A user explained that HCG is used during testosterone cycles specifically to maintain testicular function and prevent atrophy. They clarified that it should not be considered a post-cycle therapy (PCT) agent on its own.
High Dose HCG Protocol
A user recommended injecting HCG at high doses for a few weeks to stimulate the gonads by mimicking Luteinizing Hormone (LH). They suggested following this specialized HCG protocol before transitioning into a standard PCT regimen.
Synergy Between D-Aspartic Acid and HCG
A user discussed the interaction between D-Aspartic Acid and human chorionic gonadotropin, noting that D-Asp can enhance the actions of HCG. This synergy is purported to further stimulate the synthesis of testosterone.
HCG for Intratesticular Testosterone and Sperm Quality
A user highlighted research indicating that even small doses of HCG significantly increase intratesticular testosterone. They noted that this effect is essential for maintaining the production of high-quality sperm.
HCG in Sperm Morphology Protocol
A user reported using HCG and Gonadorelin (GnRH) via priming shots and pulses in an attempt to improve sperm morphology. While the specific outcome of the HCG use wasn't detailed, it was part of a targeted fertility protocol.
HCG for Semen Quality and Fertility
A user notes that HCG can substantially increase the chances of conception by improving semen parameters. They suggest specific dosing protocols, such as 1000 units three times per week or 125 units daily, to achieve these results.
hCG for Hormonal Maintenance and HRT
A user mentioned using hCG as part of a hormone replacement therapy (HRT) regimen to maintain testicular function and hormonal balance. They noted its effectiveness for its intended medical purpose rather than specifically for weight loss.
hCG for Fat Loss Success
A user shared their success using hCG injections for fat loss, noting that it felt like a 'miracle' for weight management. They reported that the protocol effectively helped them lose fat in a way other methods had not.
Significant Body Composition Improvements with hCG
A user reported a very positive experience with hCG injections, stating they helped significantly with weight loss and improving their physique. They emphasized that when used correctly, the results were highly effective for body recomposition.
Continuous Cycle Use vs. Post-Cycle
A user shared their preference for running HCG throughout the entire duration of a steroid cycle rather than waiting until the end. They found this method more effective for preventing testicular atrophy and facilitating an easier post-cycle recovery.
On-Cycle Use for Maintenance
A user reported using HCG specifically while on an anabolic steroid cycle. They noted its effectiveness for maintaining testicular function during the cycle.
Long-Term Effects on Size
One individual discussed the effects of long-term HCG use, noting significant increases in testicular size and perceived improvements in genital girth. The user inquired if others had experienced similar physiological changes.
Prevention of Testicular Degeneration
An experienced consultant highlighted that using small maintenance doses of HCG throughout a cycle prevents the degradation of Leydig cell volume and intra-testicular testosterone. They argued that using HCG during the cycle is superior to the traditional method of waiting until PCT, as it proactively maintains testicular health.
Intra-Cycle Maintenance Protocol
A user reported that following a protocol of 250IU to 500IU of HCG twice weekly during a steroid cycle successfully maintains testicular form and function. They noted that this approach prevents the 'edgy, burned-out' feeling often associated with cycles and improves daily well-being.
Effective Recovery via Intra-Cycle Use
A user shared that running HCG at low doses (250-500IU twice weekly) from the start of a cycle is the most effective method they have found for recovery. They emphasized that this prevents testicular atrophy, making the transition to post-cycle therapy much smoother as the testes remain responsive to LH.
HCG for Testicular Atrophy and Fertility
A user highlighted the effectiveness of HCG for maintaining testicular volume and fertility while on TRT. They recommended a specific dosing protocol of 500 IU to prevent testicular atrophy and support reproductive health.
HCG as LH Mimetic on TRT
A user discussed the benefits of HCG as a LH mimic to maintain natural hormonal loops while on TRT. They noted its importance in a comprehensive hormone replacement strategy to ensure overall well-being beyond just testosterone levels.
HCG for Libido and ED Improvement
A user reported that adding HCG to a TRT regimen successfully boosted libido and improved erectile function. They noted that the peptide worked effectively in cases where testosterone alone was insufficient for maintaining sex drive.
Subjective well-being and testicular restoration on TRT
A user on TRT for several years reported that adding HCG made them generally feel better. They noted that it successfully restored testicular size, sometimes exceeding original size, but warned that it increases E2 (estrogen) levels.
Managing E2 and dosing strategies with HCG
A long-term TRT user suggested using a frequent, low-dose testosterone protocol (like every other day) when incorporating HCG to manage estrogen spikes. They noted that if E2 becomes unmanageable, one might need to cycle HCG alone occasionally rather than using it concurrently with testosterone.
HCG Priming for Recovery
An individual recommends a protocol involving high-dose HCG injections for several weeks followed by a Selective Estrogen Receptor Modulator (SERM). They note it stimulates the gonads by mimicking LH.
HCG as a Test Base
A user reports that HCG can be used as a 'test base' due to it being a Luteinizing Hormone (LH) mimetic. However, they note that it is typically less effective than other conventional test base solutions.
HCG for Testicular Maintenance
A user suggests that HCG is primarily used during cycles to maintain testicular function and prevent atrophy rather than as a post-cycle therapy (PCT) agent. They describe it as a tool to keep the testes active while using suppressive substances.
HCG Interaction with D-Aspartic Acid for Testosterone Synthesis
A user discussed the relationship between D-Aspartic Acid and HCG, noting that D-Asp can potentially enhance the action of HCG. This interaction is suggested to stimulate the synthesis of testosterone.
HCG for Intratesticular Testosterone and Sperm Quality
A user noted that studies indicate even small doses of HCG can significantly increase intratesticular testosterone. This process is described as vital for maintaining the quality of sperm production.
HCG for Sperm Morphology
A user shared their experience using HCG in conjunction with Gonadorelin for improving sperm morphology. The protocol involved administering the peptide through priming shots and pulsed injections over a specific period.
HCG for Semen Quality
A user noted that HCG can substantially increase the chances of conception by improving semen parameters. They recommended specific dosing protocols of either 1000 units three times per week or 125 units daily to achieve these results.
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