A synergistic nootropic stack combining Semax (ACTH derivative for cognition) with Selank (tuftsin derivative for anxiety). Semax enhances focus, memory, and BDNF while Selank provides anxiolytic and mood-stabilizing effects without sedation.
Neural Network
Nootropic peptides enhance synaptic plasticity and neurotransmitter release.
Quickstart Highlights
- Dosage: 200-600mcg each
- Frequency: 1-2x daily (intranasal)
- Administration: Intranasal spray
- Cycle length: 4-8 weeks, cycle as needed
Dosing Plan
| Weeks | Dose | Units |
|---|---|---|
| Conservative | 200mcg each 1x daily | Morning only |
| Standard | 300mcg Semax + 200mcg Selank 2x daily | AM + early afternoon |
| Enhanced | 600mcg Semax + 400mcg Selank 2x daily | Higher dose plan |
How This Works
Semax is an ACTH(4-10) analog that increases BDNF and NGF, enhances dopamine and serotonin modulation, and has stimulatory nootropic effects. Selank is a tuftsin analog that modulates GABA and reduces anxiety without sedation while also having immune-modulating properties. Together, they create a state of calm focus - enhanced cognition without the anxiety that can accompany stimulants.
Semax
200-600mcgACTH derivative for cognition and BDNF (1-2x daily)
Selank
200-400mcgTuftsin derivative for anxiolysis and mood (1-2x daily)
Mechanism of Action
How Cognitive Works in Your Body
Peptide Administered
Crosses the blood-brain barrier
Neurotransmitter Boost
Enhances BDNF and neurotrophic factors
Synaptic Activity
Neurons fire more efficiently, forming new connections
Focus & Memory
Improved clarity, recall, and cognitive performance
Benefits & Side Effects
Potential Benefits
- Improved memory and learning
- Enhanced focus and concentration
- Reduced anxiety without sedation
- Increased BDNF levels
- Mood stabilization
- Neuroprotection
Potential Side Effects
- Nasal irritation
- Headache (rare, usually from dehydration)
- Overstimulation if Semax dose too high
- Fatigue in some (try adjusting timing)
Good to know
- Both peptides developed in Russia with clinical use history.
- Semax: Stimulating, focus-enhancing, BDNF-boosting.
- Selank: Calming, anxiolytic, mood-stabilizing.
- Together they provide focused calm - alert without anxiety.
- Intranasal for direct CNS access.
- Avoid late evening dosing (Semax may affect sleep).
- Can be alternated with NA-Semax or NA-Selank versions.
Community Insights
Summarised from 3 sourcesA synergistic nootropic stack combining Semax (ACTH derivative for cognition) with Selank (tuftsin derivative for anxiety). Semax enhances focus, memory, and BDNF while Selank provides anxiolytic and mood-stabilizing effects without sedation. Premier nootropic stack. Semax for stimulation/focus, Sel
Common Dosages Reported
- 200-600mcg each 1-2x daily (intranasal)
- Standard protocol dosing
Side Effects Mentioned
- Generally mild, individual variation expected
- See full guide for detailed safety info
Stacking Suggestions
- Consult research and healthcare provider before stacking
What people are saying
Results vary based on individual response
Consistent dosing and timing important
Reviews & Discussion
Real experiences shared by the community — not medical advice.
Cognitive Flow State and No Crash
A user highlighted that the combination provided a 'flow state' that made complex cognitive tasks feel effortless. They specifically praised the lack of a 'crash' compared to other nootropics.
Clear-headed Focus and Productivity
A user described the experience as providing a clear-headed focus and significant mental clarity without the jitters associated with traditional stimulants. They noted that the effects were subtle but highly effective for sustained productivity during the workday.
Balanced Stimulation and Reduced Anxiety
A user reported using a stack of Semax and Selank together, finding that the combination balanced stimulation with anxiolysis. They noted a reduction in social anxiety and an improved ability to articulate thoughts clearly during conversations.
Irritability and Sleep Disturbance
A user experienced significant irritability and difficulty sleeping after taking Semax later in the day. While it improved their alertness, the negative impact on mood and rest led them to discontinue evening use.
Semax and Selank for Cognitive and Stress Support
A user reported great results from using a combination of Semax and Selank. They described the stack as providing a significant boost in cognitive function, clarity, and mental sharpness. Additionally, the user noted a calming effect that helped manage stress and anxiety while maintaining focus.
Inconsistent Results with NA-Semax Nasal Spray
A user tried NA-Semax in a nasal spray format but reported that it only seemed to work once. They noted that the lack of effects might have been due to the product losing its cold temperature during shipping, though they expressed interest in trying it again.
Cognitive Enhancement and Stress Reduction Stack
A user maintaining a comprehensive peptide guide describes the Semax and Selank combination as a cognitive enhancement stack. Semax is noted for its ability to increase Brain-Derived Neurotrophic Factor (BDNF) and improve focus, while Selank is used concurrently for its anxiolytic and anti-stress properties.
Focus and Long-Term Cognitive Development
A user suggested that for those seeking focus and a 'locked-in' feeling, specific compounds like TAK-653, Bromantane, and Oxiracetam are effective. They noted that nootropics are generally intended for long-term cognitive development rather than immediate, life-changing results.
Non-Responder to Various Nootropics
A user reported that after trying numerous nootropics prior to using peptides and PEDs, they did not experience any noticeable effects or benefits. They stated that they never felt a single compound they tried.
Selank for Anxiety and Stability
A user reported that using Selank for one week to manage generalized anxiety disorder and panic disorder resulted in significant brain stability. They described the experience as life-changing, noting that their mental state had never felt more balanced.
Semax and Selank Combination for Clarity and Anxiety
A user described the combination of Semax and Selank as an excellent stack that effectively reduces anxiety while promoting clearer thinking. They identified this pair as their favorite nootropics to date.
Improved cognitive processing speed
A person reporting on their initial experience found that the stack provided a noticeable lift in cognitive processing speed. They described the effect as feeling more 'present' and capable of handling complex tasks without the typical mental fatigue that follows intense study sessions.
Potential for emotional blunting
A participant cautioned that while the stack is effective for anxiety, it can occasionally lead to a feeling of emotional blunting or being 'too level.' They suggested that the anxiolytic properties of Selank sometimes overpowered the stimulating effects of Semax, leading to decreased motivation in some instances.
Enhanced verbal fluency and memory recall
One user integrated Semax and Selank into a broader 'limitless' stack, reporting significant improvements in verbal fluency and memory recall. They emphasized that the combination felt significantly more sustainable and lacked the 'crash' associated with traditional stimulants.
Dual stack for focus and anxiety
A user shared her experience using a Semax and Selank combination, describing it as a 'calm focus.' She noted that Selank effectively reduced her social anxiety and baseline stress without sedation, while Semax provided mental clarity and helped eliminate brain fog during long work sessions.
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