Cagrilintide is a long-acting acylated analogue of the pancreatic hormone amylin, designed for once-weekly subcutaneous administration. It activates central amylin receptors to promote satiety, slow gastric emptying, and reduce food intake.
Appetite Regulation
Peptides mimic satiety hormones, reducing hunger signals from the brain.
Quickstart Highlights
- Dosage: 0.6-4.5mg
- Frequency: Weekly
- Administration: Subcutaneous
- Cycle length: Ongoing
Dosing Plan
| Weeks | Dose | Units |
|---|---|---|
| Week 1 | 0.6mg once weekly | 18 units (0.18mL) |
| Week 2 | 1.2mg once weekly | 36 units (0.36mL) |
| Week 3 | 1.8mg once weekly | 54 units (0.54mL) |
| Week 4+ | 2.4-4.5mg once weekly | 72-135 units |
How to mix
Add 3.0mL bacteriostatic water per 10mg vial → ~3.33mg/mL concentration
- Draw 3.0mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall.
- Gently swirl until dissolved.
- Label with date and store frozen at −20°C or refrigerate; use within 30 days.
Syringe Math Reference
- 10mg vial with 3mL BAC water = 3.33 mg/mL
- 1 unit = 0.01mL ≈ 33.3mcg
- 0.6mg = 18 units
- 1.2mg = 36 units
- 2.4mg = 72 units
What you'll need
Cagrilintide Vials (10mg)
- 4 weeks 1 vial
- 8 weeks 2 vials
- 12 weeks 3 vials
Insulin Syringes (U-100)
- 4 weeks 4 syringes
- 12 weeks 12 syringes
Bacteriostatic Water (10mL)
- 12 weeks 1 bottle
Alcohol Swabs
- 12 weeks 1 × 100-count box
How This Works
Cagrilintide is a long-acting acylated analog of amylin, a peptide hormone co-secreted with insulin from pancreatic beta cells. It activates amylin receptors (calcitonin receptor/RAMP complexes) in the brain to promote satiety, slow gastric emptying, and reduce food intake. The acylation extends its half-life to allow once-weekly dosing.
Mechanism of Action
How Cagrilintide Works in Your Body
Peptide Administered
Enters bloodstream and travels to target receptors
Brain Signaling
Binds to GLP-1 receptors in the hypothalamus
Appetite Reduced
Signals satiety — you feel full sooner
Fat Metabolism
Body shifts to burning stored fat for energy
Benefits & Side Effects
Potential Benefits
- Significant weight loss in clinical trials
- Reduced appetite and food cravings
- Slowed gastric emptying
- Synergy with GLP-1 agonists
- Improved metabolic parameters
Potential Side Effects
- Nausea (common, especially during titration)
- Vomiting
- Diarrhea
- Decreased appetite
- Injection site reactions
How to store it
- Lyophilized: Store frozen at −20°C (−4°F).
- Reconstituted: Refrigerate at 2–8°C; use within 30 days.
Good to know
- Long-acting amylin analog for once-weekly administration.
- Phase 2 and 3 trials show dose-dependent weight loss.
- GI side effects most common (nausea, vomiting, diarrhea).
- Often studied in combination with GLP-1 agonists for synergistic effects.
- Gradual titration essential to minimize side effects.
Community Insights
Summarised from 3 sourcesCagrilintide is a long-acting acylated analogue of the pancreatic hormone amylin, designed for once-weekly subcutaneous administration. It activates central amylin receptors to promote satiety, slow gastric emptying, and reduce food intake. Gradual titration over 4-6 weeks from 0.6mg to 4.5mg. Often
Common Dosages Reported
- 0.6-4.5mg Weekly
- Standard protocol dosing
Side Effects Mentioned
- Generally mild, individual variation expected
- See full guide for detailed safety info
Stacking Suggestions
- Consult research and healthcare provider before stacking
What people are saying
Results vary based on individual response
Consistent dosing and timing important
Reviews & Discussion
Real experiences shared by the community — not medical advice.
Cagrilintide Potency Comparison
A user reported that Cagrilintide is more effective for weight loss than Retatrutide. They noted it is also more powerful than Tirzepatide, though it is more expensive.
Stacking Cagrilintide for Maximum Results
A user discussed the potential for maximizing weight loss results by stacking Tirzepatide, Cagrilintide, and Retatrutide. The combination is intended to target multiple metabolic pathways for enhanced fat loss.
Severe Persistent Hiccups from Combination Therapy
A user reported experiencing "round the clock hiccuping" for over two weeks after combining 1mg of Cagrilintide with 10mg of Retatrutide every five days. They stated they would not repeat this combination again due to the severity of the side effect.
Mood changes after three weeks
A user reported experiencing noticeable changes in their mood during their third week of taking Cagrilintide. They shared these observations while seeking feedback from others regarding similar emotional or psychological side effects.
Switching from SEMA to SEMA/cagrilintide (Cagrisema)
A user reported that their research subject has been on micro-doses of semaglutide for two months and is switching to a combined semaglutide and cagrilintide protocol. While they feel physically excellent, they noted that weight loss has been very slow on semaglutide alone.
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