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Thymosin Alpha-1 1 min read January 28, 2026

What is Thymosin Alpha1?

## What is Thymosin Alpha-1? Thymosin alpha-1 is peptide containing 28 amino acid residues that are N-terminally acetylated and proteolytically processed from prothymosin alpha. Thymosin alpha-1 was isolated by Goldstein and coworkers from thymosin fraction 5, a mixture of peptides from calf thymus in the 1970s. It is used to improve immune responses in times of need.

What is Thymosin Alpha-1? Thymosin alpha-1 is peptide containing 28 amino acid residues that are N-terminally acetylated and proteolytically processed from prothymosin alpha. Thymosin alpha-1 was isolated by Goldstein and coworkers from thymosin fraction 5, a mixture of peptides from calf thymus in the 1970s. It is used to improve immune responses in times of need.

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Immune Function Thymosin Alpha-1

Related Peptides

Thymosin Alpha-1

Immune modulating peptide for enhanced T-cell function and infection resistance. Thymosin Alpha-1 (TA1) is a naturally occurring thymic peptide that is FDA-approved in over 35 countries under the brand name Zadaxin for hepatitis B/C and as a vaccine adjuvant. It modulates T-cell function without overstimulating the immune system.

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Thymosin Alpha-1/LL-37 Blend

Comprehensive immune support with T-cell and antimicrobial action

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History of Thymosin Alpha-1

Thymosin Alpha-1 is a biologically active peptide derived from prothymosin-alpha. Current hypotheses consider Thymosin Alpha-1 to be the main constituent of Thymosin Fraction-5, and as such it is considered to be the active component that restores the immune function in both athymic animals and animals with dysfunctional thymus glands. [Thymosin Alpha-1](https://en.wikipedia.org/wiki/Thymosin_%CE%B11 "thymosin alpha 1") was among the first peptide isolates of Thymosin Fraction-5 to be sequenced

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How does Thymosin Alpha 1 improve anti-viral immune responses?

“Importantly, **Ta1 acts without overstimulation of cytokine production** and is generally well tolerated; it has an excellent safety profile and does not appear to induce the side effects and toxicities commonly associated with agents in this class such as interferon alpha and interleukin-2.” (1) “Clinical trials using Ta1 in the treatment of patients with immunodeficiency or cancer indicate that this agent is nontoxic, enhances immune

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​Immune Function and the Gut and Thymosin Alpha1

Thymosin Alpha-1 is a major component of Thymosin Fraction 5 found in the thymus. The thymus is responsible for regulating the immune system. Thymosin Alpha-1 is prescribed to optimize the performance of your immune health and improve general wellness by preventing infections such as the common cold or the flu. It acts to augment T-cell function; T-cells are a part of the adaptive immune system which fights off infection.

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