Linear analog of alpha-melanocyte-stimulating hormone (α-MSH) that selectively activates MC1R receptors for melanogenesis. Studied for photoprotection and tanning without the broader melanocortin effects of Melanotan II.
Collagen & Keratin
Stimulates fibroblasts and follicles for firmer skin and thicker hair.
Quickstart Highlights
- Dosage: 250-1000mcg
- Frequency: 2-3x weekly
- Administration: Subcutaneous
- Cycle length: 4-8 weeks
How This Works
Mechanism of Action
How Melanotan Works in Your Body
Peptide Administered
Targets skin and hair follicle cells
Cellular Stimulation
Activates fibroblasts and follicle stem cells
Collagen & Keratin
Boosts production of structural proteins
Visible Results
Firmer skin, reduced wrinkles, thicker hair
Benefits & Side Effects
Potential Benefits
- Melanogenesis
- Photoprotection
- Tanning
- UV damage reduction
Quick notes
Monitor pigmentation changes. Fewer side effects than Melanotan II (no libido/appetite effects).
References
Community Insights
Summarised from 6 sourcesMelanotan I, also known as Afamelanotide, is discussed on Reddit primarily for its ability to help individuals tan, particularly those with very fair skin or sun allergies. Users report using it to achieve a tan that they otherwise cannot, and to reduce skin sensitivity to the sun. There is interest in obtaining it through compounding pharmacies with a prescription, and discussions around proper reconstitution and dosage.
Key Benefits
- Helps achieve a tan, especially for fair-skinned individuals.
- Reduces sun sensitivity/allergies.
- Darkens freckles and moles (even without sun exposure).
Common Dosages Reported
- 150-250 mcg daily (for nearly a month).
- 300 mcg for a week before sun exposure.
- 250-500 mcg minimum, with 1ML being appropriate for reconstitution.
Side Effects Mentioned
- Darkening of freckles and moles (may be considered a side effect by some).
What people are saying
"Afamelanotide in particular. Which is “melanotan 1”. Trust me, I've used every kind of sunblock, sunscreen, and..."
"I did about 300 mcg for a week before I was able to layout in the Sun. Without Sun I noticed my freckles and moles really darken quite a bit..."
Reviews & Discussion
Real experiences shared by the community — not medical advice.
Melanotan Dosage and Efficacy by Skin Type
A user shared guidelines for using Melanotan based on the Fitzpatrick scale, noting that individuals with lighter skin (Types I and II) typically require 20-30mg to achieve a decent tan. Darker skin types generally require significantly less, often under 10mg. The user described the peptide as the best tanning product available.
Discussion on Melanocortin Receptor Benefits and Safety
A user discussed the relative safety of Melanotan II and its close relative PT-141, noting that MT-II activates the MC4 receptor which may offer neuroprotective benefits. They argued that while not risk-free, documented harms are generally associated with extremely heavy use rather than standard protocols.
Lack of Tanning Effect
A user reported that after nearly a month of consistent use coupled with daily sun exposure, the peptide failed to change their complexion. The only noticeable effects were the appearance of a few additional freckles.
Extreme Physical Hypersensitivity Side Effects
A user experienced extreme physical discomfort, reporting hypersensitivity that made walking difficult. They noted that even minor vibrations caused intense, overwhelming sensitivity in their genital area, leading them to conclude the experience was not worth it.
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