The foundational healing peptide stack combining TB-500 (systemic wound healing) with BPC-157 (localized tissue repair). This synergistic duo is the most popular combination for injury recovery, addressing healing through complementary mechanisms: systemic repair (TB-500) and targeted tissue healing (BPC-157).
Tissue Repair
Healing peptides accelerate collagen deposition and reduce inflammation.
Quickstart Highlights
- Dosage: TB-500: 2-5mg/wk | BPC-157: 250-500mcg/day
- Frequency: TB-500: 2x/week | BPC-157: 1-2x/day
- Administration: Subcutaneous (near injury or systemic)
- Cycle length: 6-12 weeks
Dosing Plan
| Weeks | Dose | Units |
|---|---|---|
| Weeks 1–2 (Loading) | TB-500 2.5mg 2x/wk + BPC 500mcg 2x/day | TB: 100 units 2x/wk | BPC: 20 units 2x/day |
| Weeks 3–6 | TB-500 2.5mg 2x/wk + BPC 500mcg 1x/day | TB: 100 units 2x/wk | BPC: 20 units daily |
| Weeks 7–12 (Maintenance) | TB-500 2.5mg 1x/wk + BPC 250mcg 1x/day | TB: 100 units weekly | BPC: 10 units daily |
How to mix
- TB-500 (5mg): Add 2mL BAC water → 2.5mg/mL concentration.
- BPC-157 (5mg): Add 2mL BAC water → 2.5mg/mL (250mcg/0.1mL).
- Inject slowly down vial wall.
- Swirl gently until dissolved.
- Label with date and concentration.
- Refrigerate at 2–8°C.
Syringe Math Reference
- TB-500 (2.5mg/mL): 2.5mg = 100 units (1mL), 5mg = 200 units (requires 2 injections)
- BPC-157 (2.5mg/mL): 250mcg = 10 units, 500mcg = 20 units
What you'll need
TB-500 Vials (5mg)
- 4 weeks (loading) 4 vials
- 12 weeks 8-10 vials
BPC-157 Vials (5mg)
- 4 weeks (500mcg/day) 3 vials
- 12 weeks 6-8 vials
Insulin Syringes (U-100)
- 4 weeks 60 syringes
- 12 weeks 150 syringes
Bacteriostatic Water (10mL)
- 12 weeks 4 bottles
How This Works
TB-500 promotes wound healing through multiple mechanisms: it regulates actin (a cell-building protein), promotes angiogenesis (new blood vessel formation), reduces inflammation, and enhances cell migration to injury sites. BPC-157 accelerates healing through growth factor modulation (VEGF, EGF, FGF), nitric oxide system effects, and unique interactions with the gut-brain axis. Together, they address healing at both systemic and local levels.
TB-500
5mg vialThymosin Beta-4 synthetic fragment for systemic wound healing and angiogenesis
BPC-157
5mg vialBody Protection Compound for tendon, ligament, muscle, and gut healing
Mechanism of Action
How TB-500 Works in Your Body
Peptide Administered
Reaches the site of injury or inflammation
Inflammation Control
Modulates inflammatory pathways at the source
Cell Repair
Accelerates fibroblast activity and collagen synthesis
Tissue Heals
Tendons, gut lining, or muscles recover faster
Benefits & Side Effects
Potential Benefits
- Dramatically accelerated injury recovery
- Tendon and ligament repair
- Muscle tear healing
- Improved joint health
- Reduced inflammation and pain
- Enhanced flexibility (TB-500)
- Gut lining repair (BPC-157)
Potential Side Effects
- Injection site reactions (mild, transient)
- Temporary fatigue during intense healing
- Head rush (TB-500, rare)
- Nausea (BPC-157, rare)
- Generally extremely well tolerated
How to store it
- Both peptides: Refrigerate after reconstitution at 2–8°C.
- TB-500: Use within 2-3 weeks reconstituted (less stable than BPC).
- BPC-157: Use within 4 weeks reconstituted.
- Lyophilized: Store frozen for long-term.
Good to know
- BPC-157 can be injected subcutaneously near the injury site for localized healing.
- TB-500 is more systemic - inject anywhere subcutaneously.
- Loading phase (weeks 1-2) is important for acute injuries.
- These peptides work synergistically - effects enhanced together.
- BPC-157 also has significant gut healing properties.
- Very well tolerated with minimal side effects.
- Can continue until injury is fully healed.
Community Insights
Summarised from 4 sourcesThe foundational healing peptide stack combining TB-500 (systemic wound healing) with BPC-157 (localized tissue repair). This synergistic duo is the most popular combination for injury recovery, addressing healing through complementary mechanisms: systemic repair (TB-500) and targeted tissue healing
Common Dosages Reported
- TB-500: 2-5mg/wk | BPC-157: 250-500mcg/day TB-500: 2x/week | BPC-157: 1-2x/day
- Standard protocol dosing
Side Effects Mentioned
- Generally mild, individual variation expected
- See full guide for detailed safety info
Stacking Suggestions
- Consult research and healthcare provider before stacking
What people are saying
Results vary based on individual response
Consistent dosing and timing important
Reviews & Discussion
Real experiences shared by the community — not medical advice.
Effective Healing for Severe Knee Injuries
A user reported significant benefits from using a BPC-157 and TB-500 stack to treat a serious injury involving a torn ACL, MCL, and meniscus. They noted that the combination was highly effective for healing, particularly when TB-500 was used to address systemic inflammation while BPC-157 was injected locally.
Support for Post-Concussion Syndrome Recovery
One individual shared that the combination of TB-500 and BPC-157 was helpful for managing symptoms of post-concussion syndrome and related systemic issues. They emphasized the importance of using both together to address different aspects of recovery and inflammation.
Recovery Support for mTBI symptoms
A user discussed utilizing a BPC-157 and TB-500 stack to aid in recovery from a mild traumatic brain injury (mTBI). They found the combination useful for reducing neuroinflammation and supporting general physical repair during their rehabilitation process.
Synergistic Results with BPC-157/TB-500 Stack
A user shared that stacking BPC-157 and TB-500 provided better healing results for their injuries than using either peptide alone. They noted that the combination seemed to create a synergistic effect that accelerated recovery.
BPC-157 for Lower Back Pain Relief
A user reported significant relief from chronic lower back pain after incorporating BPC-157 into their recovery regimen. They emphasized the importance of consistent dosing to manage systemic inflammation and localized discomfort.
BPC-157 for Herniated Disc Support
A user successfully used BPC-157 to manage the discomfort associated with herniated discs. They found that the peptide helped reduce inflammation and helped them return to their bodybuilding training more quickly.
Significant Pain Relief and Recovery for Rotator Cuff Tear
A user experienced pain relief within one to two days of using BPC-157 for a partial rotator cuff tear, which they initially attributed to reduced inflammation. After two cycles of use, they reported that the pain has not returned, though they have not had follow-up imaging to confirm if the tissue has fully healed mathematically.
Successful Recovery with BPC-157 and TB-500 Stack
A user reported achieving the best results for ligament injury recovery by using a stack of BPC-157 and TB-500. They noted that individual preferences vary, but this specific combination was the most effective for their own healing needs.
BPC-157/TB-500 for Anti-Aging and Inflammation
A user reported using a BPC-157 and TB-500 stack for anti-aging and anti-inflammatory benefits. They noted that they began their regimen slowly and opted for subcutaneous injections over intra-articular ones after finding the latter less effective for joint-specific issues.
Stacking TB-500 and BPC-157 for Injury Recovery
A user is currently stacking TB-500 and BPC-157 to address a physical injury. They expressed interest in further expanding their stack with ARA-290 to specifically target neuropathy symptoms.
BPC-157/TB-500 Blend for Knee Injury
A user is initiating a treatment for a nagging knee injury using a 5mg/5mg blend of BPC-157 and TB-500. They are seeking specific dosing protocols for this combination to maximize tissue repair and wound healing.
Nerve Injury Recovery with BPC-157
A user successfully healed a two-year-old nerve injury over a six-month period using 100-200 mcg of BPC-157 twice daily, administered subQ directly over the injured area. They described the injury as 'truly healed.'
Positive Results with Twice-Daily BPC-157 Dosing
A user reported great results for injury recovery using 400 mcg of BPC-157 twice daily. However, they advise against pinning pre-workout to avoid interfering with natural inflammation and potentially causing excessive blood flow at the injury site.
Anhedonia and Reduced Stimulant Sensitivity
A user reported experiencing anhedonia and a significant reduction in the effects of caffeine while using BPC-157. Another contributor hypothesized that the peptide might block the effects of stimulants.
BPC-157/TB-500 Stack for Ankle Sprain and Fracture
A user found that a combination of low-dose BPC-157 (250-500 mcg) and TB-500 'worked wonders' for a nagging ankle sprain that had persisted for a year, completely resolving the issue. They subsequently increased dosages to 2 mg daily for both peptides to treat a new bone fracture.
BPC-157 and TB-500 for SI Joint Strain
A user reported significant improvement in SI joint strain after using 300 mcg of BPC-157 twice daily for two weeks, followed by adding 2.5 mg of TB-500 every three days. While effective, the user noted that the results were helpful but not a 'miracle' cure.
Two-Week BPC-157 Results and Future TB-500 Stack
A user reported feeling amazing after using BPC-157 for only two weeks. They noted that the peptide is "one of a kind" and expressed plans to continue their regimen by stacking it with TB-500.
Recovery from Long-term Knee Injury and Recent Pain
A user shared their success using a combination of BPC-157 and TB-500 to address a decade-old knee injury from marathon training. They also noted significant relief from more recent pain in their chest and forearm after starting the regimen.
Severe Osteoarthritis and Seeking Relief
A user suffering from erosive degenerative osteoarthritis in every joint expressed extreme difficulty with daily tasks and chronic pain. They are investigating stacks like BPC-157 and TB-500 as potential interventions for their severe mobility issues and systemic inflammation.
Rotator Cuff Recovery with TRT Stack
A 54-year-old user on TRT reported using a BPC-157 and TB-500 stack to successfully treat a torn rotator cuff. They noted that the combination significantly improved their recovery and allowed them to return to the gym within a few months.
Peptide Use for Severe Eye Injury
A user sought to use a BPC-157 and TB-500 blend to assist in healing a severe eye injury. While they were optimistic about the systemic healing properties of the peptides, they were primarily seeking advice on appropriate dosing protocols for acute trauma.
BPC-157, TB-500, and IGF-1 LR3 Combination
A user inquired about the safety of combining BPC-157 and TB-500 with IGF-1 LR3 for a clinical injection session. The discussion focused on the potential synergistic effects of these peptides on tissue repair and systemic growth factor levels.
No discussion yet — be the first.
No notes yet — be the first.