A user reported losing 81 lbs (from 391 lbs to 310 lbs) over approximately eight months using Retatrutide, reaching a maximum dose of 10 mg/week. They noted significant improvements in health markers, including moving from pre-diabetic to a normal HbA1c range and better lipid profiles. After stopping the peptide for five weeks to resensitize, they observed that appetite suppression lasted about three weeks, after which overeating urges and impulsive binging returned.