Post-cycle therapy for HPTA recovery
Endocrine Signaling
Hormonal peptides modulate release along the endocrine axis.
Quickstart Highlights
- Dosage: HCG 1000iu + Gonadorelin 200mcg + Kisspeptin 100mcg
- Frequency: EOD first 2 weeks, then 3x weekly
- Administration: Subcutaneous
- Cycle length: 4-6 weeks
How This Works
HCG
1000iuGonadorelin
200mcgKisspeptin
100mcgMechanism of Action
How PCT Works in Your Body
Peptide Administered
Enters the bloodstream via injection
Receptor Binding
Finds and activates its target receptor
Signal Cascade
Triggers a chain of cellular responses
Biological Effect
The body produces the desired outcome
Benefits & Side Effects
Potential Benefits
- HPTA recovery
- Natural testosterone restoration
- Fertility
- Testicular function
Quick notes
Higher doses first 2 weeks, then taper. Combine with traditional PCT if needed
Community Insights
Summarised from 3 sourcesPost-cycle therapy for HPTA recovery Higher doses first 2 weeks, then taper. Combine with traditional PCT if needed
Common Dosages Reported
- HCG 1000iu + Gonadorelin 200mcg + Kisspeptin 100mcg EOD first 2 weeks, then 3x weekly
- Standard protocol dosing
Side Effects Mentioned
- Generally mild, individual variation expected
- See full guide for detailed safety info
Stacking Suggestions
- Consult research and healthcare provider before stacking
What people are saying
Results vary based on individual response
Consistent dosing and timing important
Reviews & Discussion
Real experiences shared by the community — not medical advice.
Natural PCT Stack for Muscle Retention
A user planned a post-cycle therapy (PCT) stack following a "natural" performance-enhancing cycle, incorporating HCGenerate as a primary component. They expressed confidence in using the stack to maintain gains and recover hormone levels effectively.
SARMs PCT Stack Requirements and Information
A user requested information on upgrading their PCT stack for a RAD-140 and potential LGD-4033 cycle, moving beyond basic DHEA and natural test boosters. Responses indicated that a standard effective PCT stack involves Clomid at 50/50/25/25 or Nolvadex to properly restart the HPTA, noting that Clomid is particularly effective for fertility but may cause emotional side effects.
10 Week LGD / Dermacrine Cycle and PCT Stack Plan
A user outlined a comprehensive 12-week LGD-4033 and Dermacrine cycle featuring a robust PCT stack. The proposed PCT includes Clomid (50/50/25/25/12) and Nolvadex (20/20/10/10), supplemented with natural support agents like Hawthorn Berry and Cissus.
Testosterone Enanthate PCT Protocol Discussion
A user planning a Post Cycle Therapy (PCT) after 500mg of Testosterone Enanthate inquired about using a single SERM versus a combination. Another member recommended a combined stack of Nolvadex and Clomid, suggesting Nolvadex at 10mg for six weeks alongside Clomid at 25mg for three weeks and 12.5mg for one week.
Negative Reaction to TRT and HCG Lead to Treatment Cessation
A user experienced a severe loss of libido and erectile function after only two weeks of a TRT protocol involving Testosterone Cypionate and low-dose HCG. Due to these negative side effects, the user decided to discontinue the treatment and sought advice on whether a PCT was necessary to return to their baseline hormonal state.
Proposed PCT Stack with HCG, Tamoxifen, and Arimidex
A user planned a post-cycle therapy (PCT) stack following a 9-week testosterone and oral steroid cycle. The proposed protocol included high-dose HCG (1500 IU every 3 days) for two weeks, followed by Tamoxifen (Nolvadex) and continuous use of Arimidex to manage potential estrogen spikes.
Persistent Sexual Dysfunction Despite High Testosterone on PCT Stack
A user reported persistent sexual dysfunction, including low libido and poor erections, despite having high testosterone levels (1110 ng/dL) during a PCT stack of Clomid and Tamoxifen. They noted that their initial PCT attempt failed due to counterfeit products and expressed Concern that their current recovery protocol was not restoring sexual health.
Early Stage PCT Preparation and Monitoring
A user reported purchasing HCG and Arimidex for PCT but stated it was too early to determine their effectiveness. They mentioned plans to use Nolvadex and Clomid in several months once their current cycle concludes.
Enclomiphene Recovery after 10-month Suppression
A user reported achieving a total testosterone level of 600 ng/dl after just two weeks of a PCT protocol using 25mg of Enclomiphene daily. This recovery followed a 10-month suppression period, though the user noted that LH and FSH levels had not yet returned to their higher baseline values and observed a minor impact on liver enzymes.
PCT with Clomid, Nolvadex, and HCG after 16-week cycle
A user reported successfully completing a 16-week cycle with a PCT stack consisting of Clomid, Nolvadex, and HCG. They utilized high initial doses (150mg Clomid and 1500IU HCG) and expressed satisfaction with the results of their overall protocol despite experiencing some sexual side effects during the later stages of the cycle.
PCT for Hormonal Recovery and LH/FSH Stimulation
A user described PCT as a vital testosterone recovery strategy using SERMs to stimulate Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). This process is intended to kickstart natural testosterone production and ensure a successful recovery after a cycle.
Enclomiphene Recommended as Primary PCT Tool
A user recommended Enclomiphene as the superior Selective Estrogen Receptor Modulator (SERM) for a post-cycle therapy (PCT) stack following a SARM cycle. They noted that while Nolva or Clomid are viable alternatives, Enclomiphene remains the best option for mitigating side effects and supporting recovery.
Ashwagandha for Anxiety Management During PCT
A user reported utilizing Ashwagandha to successfully manage anxiety during post-cycle therapy (PCT) following a cycle of Sustanon and MK-677. They highlighted it as one of the most effective supplements in their regimen alongside caffeine and l-theanine.
Proposed RAD-140 and Peptide Stack with Clomid PCT
A user proposed an eight-week cycle combining Retatrutide, "Glow" (likely a GHRH/GHRP blend), and the SARM RAD-140, followed by a four-week PCT using Clomid. The user, aged 20, sought feedback on the safety and efficacy of this specific anabolic and peptide combination.
Perspective on Peptide PCT Necessity
A community member commented that most peptides do not require a post-cycle therapy (PCT). They argued that these compounds generally do not suppress natural hormone production to a degree that justifies a complex recovery protocol.
Proposed PCT with HCG and Tamoxifen focus on Estrogen Control
A user planning a 9-week moderate testosterone and oral steroid cycle proposed a PCT using HCG (1500 IU every 3 days for 2 weeks) followed by Tamoxifen (20/20/10). He expressed significant concern regarding estrogen spikes during the recovery phase and considered using Arimidex throughout the entire PCT period.
Rapid Loss of Libido on Short-Term TRT and HCG
A user briefly attempted a TRT and HCG protocol (150iu M/W/F) for two weeks but decided to stop after experiencing a complete loss of libido and erectile quality. He sought advice on whether a PCT was necessary after only two weeks of exogenous testosterone use and a total of 250mg injected.
Sexual Dysfunction Post-Cycle Despite High Testosterone
A user completed a 16-week cycle of 500mg testosterone and Anavar, followed by a PCT of Clomid (100mg then 50mg) and Tamoxifen (20mg). Despite achieving high testosterone levels (1110 ng/dL), he reported persistent issues with libido, arousal, and erectile dysfunction. The user expressed concern over these sexual side effects even though his hormonal labs appeared otherwise good.
Initial Experience with HCG and Arimidex PCT
A reviewer reported using a PCT stack including HCG and Arimidex following a cycle of Test-C. While it was too early to confirm full efficacy of the PCT, the user found the communication and overall product quality from the source to be satisfactory, despite experiencing significant post-injection pain (PIP) from the testosterone base.
Enclomiphene and HCG for Long-Term Recovery
A user shared their successful recovery using Enclomiphene (25mg daily) and HCG after a 10-month 'TRT+' regimen. After two weeks of Enclomiphene, their total testosterone reached 600 ng/dl, though they noted a slight increase in liver enzymes (AST), suggesting a minor burden on the liver.
PCT Stack following Test, Anavar, and Winstrol Cycle
A user reported using a PCT stack consisting of Clomid (100mg), Nolvadex (20mg), and HCG (1500IU) after a 16-week cycle. They noted that while the overall cycle was successful, the addition of Winstrol prior to PCT caused sexual dysfunction, including loss of erection and inability to orgasm.
Mechanism of SERMs in PCT Recovery
A contributor explains that the primary function of a PCT stack using SERMs is to stimulate Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). This process is intended to kickstart natural testosterone production and ensure a successful recovery after a suppressive cycle.
RAD 140 Cycle Effects and Potency
A user described their experience with RAD 140, noting significant muscle size gains along with increased libido and aggression. They compared its potency to a milder version of S23 but did not specify their post-cycle recovery protocol.
Enclomiphene as Preferred PCT SERM
A user recommends a Post Cycle Therapy (PCT) stack consisting primarily of a Selective Estrogen Receptor Modulator (SERM). They highlight Enclomiphene as the superior choice for recovery, though they note Nolvadex or Clomid are viable alternatives for restarting natural hormone production.
Ashwagandha for PCT Anxiety
A user reported that Ashwagandha was highly effective in managing anxiety during post-cycle therapy (PCT) after using MK-677 and Sustanon. They ranked it as one of their most effective supplements alongside caffeine and l-theanine.
Mucuna Pruriens as Natural PCT Support
A user noted that Mucuna Pruriens can be utilized as a natural testosterone booster or as part of a post-cycle therapy (PCT) regimen. They observed benefits including increased testosterone, lower prolactin, lower cortisol, and improved sleep quality.
Peptide Necessity for PCT
A forum member advised that peptides generally do not require a post-cycle therapy (PCT) because they do not suppress natural hormone production to a significant degree. The user suggested that individuals often overthink the hormonal impact of these compounds.
Proposed Retatruitide and RAD-140 Cycle with Clomid PCT
A user shared a plan to run an 8-week cycle of Retatruitide, RAD-140, and 'Glow' (typically a GHK-Cu/BPC-157/TB-500 blend), followed by a 4-week Clomid post-cycle therapy (PCT). The individual sought feedback on this stack for performance and recovery at age 20.
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