A user reported losing 81 lbs (averaging 9.5 lbs per month) specifically while using GLP-1 agonists, reaching a total loss of 100 lbs. They noted dramatic improvements in health markers, shifting from pre-diabetic status to a normal HbA1c range and seeing improved lipid profiles. However, they observed that food urges and bingeing tendencies returned approximately three to five weeks after discontinuing the medication.