A user reported that AICAR acts as an AMPK activator, which can induce a cellular state similar to intensive exercise or low caloric intake. The user noted that while it has shown impressive fat-loss and endurance-enhancing effects in laboratory animals, its effectiveness in bodybuilding at lower doses remains equivocal. Additionally, the user mentioned that its use by elite athletes has historically been prohibitively expensive due to the high dosages required for metabolic shifts.